| Gene Symbol |
GCNT3
|
| Entrez Gene |
9245
|
| Alt Symbol |
C2/4GnT, C24GNT, C2GNT2, C2GNTM, GNTM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glucosaminyl (N-acetyl) transferase 3, mucin type
|
| Other Description |
C2GnT-mucin type|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3|beta1,6-N-acetylglucosaminyltransferase-M|beta1,6GlcNAc-transferase|core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase|hC2GnT-M|mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase
|
| Swissprots |
O95395
|
| Accessions |
CAC17334 CAC34676 EAW77571 EAW77572 O95395 AF038650 AAD21525 AF102542 AAD10824 AK312852 BAG35705 BC017032 AAH17032 BP243086 EF152283 ABM21534 HQ448271 ADQ32751 NM_004751 NP_004742
|
| Function |
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. {ECO:0000269|PubMed:9915862}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced. {ECO:0000269|PubMed:17303715, ECO:0000269|PubMed:9915862}.
|
| Top Pathways |
Mucin type O-Glycan biosynthesis
|
![Western Blot: GCNT3 Overexpression Lysate (Adult Normal) [NBL1-11016] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GCNT3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1565_GCNT3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11016-img0002.jpg)