Gene Symbol | GCNT3 |
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Entrez Gene | 9245 |
Alt Symbol | C2/4GnT, C24GNT, C2GNT2, C2GNTM, GNTM |
Species | Human |
Gene Type | protein-coding |
Description | glucosaminyl (N-acetyl) transferase 3, mucin type |
Other Description | C2GnT-mucin type|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3|beta1,6-N-acetylglucosaminyltransferase-M|beta1,6GlcNAc-transferase|core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase|hC2GnT-M|mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase |
Swissprots | O95395 |
Accessions | CAC17334 CAC34676 EAW77571 EAW77572 O95395 AF038650 AAD21525 AF102542 AAD10824 AK312852 BAG35705 BC017032 AAH17032 BP243086 EF152283 ABM21534 HQ448271 ADQ32751 NM_004751 NP_004742 |
Function | Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. {ECO:0000269|PubMed:9915862}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced. {ECO:0000269|PubMed:17303715, ECO:0000269|PubMed:9915862}. |
Top Pathways | Mucin type O-Glycan biosynthesis |
Human GCNT3 full length protein - ab160399 from Abcam
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Human GCNT3 protein fragment - ab160400 from Abcam
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GCNT3 Antibody Blocking Peptide - LS-E636 from LifeSpan Bioscience
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GCNT3 Antibody Blocking Peptide - LS-E4518 from LifeSpan Bioscience
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GCNT3 Antibody Blocking Peptide - LS-E16014 from LifeSpan Bioscience
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GCNT3 Antibody Blocking Peptide - LS-E26569 from LifeSpan Bioscience
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GCNT3 Antibody Blocking Peptide - LS-E26568 from LifeSpan Bioscience
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GCNT3 Antibody Blocking Peptide - LS-E29618 from LifeSpan Bioscience
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GCNT3 Antibody Blocking Peptide - LS-E29619 from LifeSpan Bioscience
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GCNT3 Antibody Blocking Peptide - LS-E29813 from LifeSpan Bioscience
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GCNT3 Antibody Blocking Peptide - LS-E29812 from LifeSpan Bioscience
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Recombinant Human GCNT3 Protein - H00009245-Q01 from Novus Biologicals
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Recombinant Human GCNT3 Protein - H00009245-P01 from Novus Biologicals
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GCNT3-Antibody-C-term-Blocking-peptide - BP10975b from Abgent, a WuXi AppTec company
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GCNT3-Antibody-N-term-Blocking-Peptide - BP16849a from Abgent, a WuXi AppTec company
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GCNT3 (aa 273 to 284) blocking peptide - GTX88861-PEP from GeneTex
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GCNT3 (aa 410 to 422) blocking peptide - GTX88863-PEP from GeneTex
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GCNT3 Blocking Peptide - 33R-1261 from Fitzgerald
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GCNT3 Peptide - AC21-1404-P from Abcore
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GCNT3 Peptide - AC21-1405-P from Abcore
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GCNT3 - H00009245-P01-10 from Acris Antibodies
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GCNT3 - H00009245-P01-25 from Acris Antibodies
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GCNT3 - H00009245-Q01-10 from Acris Antibodies
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GCNT3 - H00009245-Q01-25 from Acris Antibodies
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GCNT3 Peptide - 46-664P from ProSci
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