| Gene Symbol | GCNT3 |
|---|---|
| Entrez Gene | 9245 |
| Alt Symbol | C2/4GnT, C24GNT, C2GNT2, C2GNTM, GNTM |
| Species | Human |
| Gene Type | protein-coding |
| Description | glucosaminyl (N-acetyl) transferase 3, mucin type |
| Other Description | C2GnT-mucin type|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3|beta1,6-N-acetylglucosaminyltransferase-M|beta1,6GlcNAc-transferase|core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase|hC2GnT-M|mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase |
| Swissprots | O95395 |
| Accessions | CAC17334 CAC34676 EAW77571 EAW77572 O95395 AF038650 AAD21525 AF102542 AAD10824 AK312852 BAG35705 BC017032 AAH17032 BP243086 EF152283 ABM21534 HQ448271 ADQ32751 NM_004751 NP_004742 |
| Function | Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. {ECO:0000269|PubMed:9915862}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced. {ECO:0000269|PubMed:17303715, ECO:0000269|PubMed:9915862}. |
| Top Pathways | Mucin type O-Glycan biosynthesis |