| Gene Symbol | Dio3 |
|---|---|
| Entrez Gene | 107585 |
| Alt Symbol | - |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | deiodinase, iodothyronine type III |
| Other Description | 5DIII|DIOIII|type 3 DI|type III iodothyronine deiodinase|type-III 5'-deiodinase |
| Swissprots | Q91ZI8 G3UY28 Q3UKD2 |
| Accessions | AAL23960 EDL18680 Q91ZI8 AK140797 BAE24483 AK146060 BAE26869 AU017368 BC106847 AAI06848 BC106848 AAI06849 BX638763 NM_172119 NP_742117 |
| Function | Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Mouse Dio3 cDNA clone(NM_172119.2) - CDFL003640 from Creative Biomart
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Mouse Dio3 ORF Clone(NM_172119.2) - CDCR270638 from Creative Biomart
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Mouse Dio3 ORF Clone(NM_172119.2) - CDCR270757 from Creative Biomart
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Mouse Dio3 ORF Clone(NM_172119.2) - CDCL161079 from Creative Biomart
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Mouse Dio3 ORF clone (NM_172119.2) - CDCR055614 from Creative biogene
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Mouse Dio3 cDNA Clone(NM_172119.2) - CDFL003640 from Creative biogene
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