GPS1

Gene Symbol	GPS1
Entrez Gene	2873
Alt Symbol	COPS1, CSN1
Species	Human
Gene Type	protein-coding
Description	G protein pathway suppressor 1
Other Description	COP9 signalosome complex subunit 1|COP9 signalosome subunit 1|GPS-1|JAB1-containing signalosome subunit 1|SGN1|signalosome subunit 1
Swissprots	Q8NA10 Q9BWL1 Q13098
Accessions	EAW89741 EAW89742 Q13098 AB209596 BAD92833 AK026610 AK093283 BAC04120 AK222508 AK225248 AK289435 BAF82124 AK297872 BAG60198 BC000155 AAH00155 BC064503 AAH64503 BG775520 BT009834 AAP88836 EU832312 ACE87569 EU832397 ACE86882 HQ258557 ADR83311 U20285 AAC50906 XM_005256350 XP_005256407 XM_005256351 XP_005256408 XM_005256353 XP_005256410 XM_005256354 XP_005256411 XM_005256357 XP_005256414 XM_005256358 XP_005256415 XM_005256359 XP_005256416 XM_005256360 XP_005256417 XM_005256362 XP_005256419 XM_005256363 XP_005256420 XM_011523563 XP_011521865 XM_011523564 XP_011521866 XM_011523565 XP_011521867 XM_011523566 XP_011521868 XM_011523567 XP_011521869 XM_011523568 XP_011521870 XM_011523569 XP_011521871 XM_011523570 XP_011521872 NM_004127 NP_004118 NM_212492 NP_997657
Function	Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:8943324}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GPS1-Over-expression-Lysate - LY12657a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

GPS1 293T Cell Transient Overexpression Lysate(Denatured) - H00002873-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GPS1 overexpression lysate - LY418202 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GPS1 293 Cell Lysate - 408493 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CSN1 Overexpression Lysate (Denatured) - H00002873-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

CSN1 Overexpression Lysate (Native) - NBL1-11308 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CSN1 (h): 293T Lysate - sc-110484 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

GPS1 Over-expression Lysate Product - GWB-AD7320 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

CSN1 Overexpression Lysate (Native) - NBP2-04487 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human GPS1 Knockdown Stable Cell Line - CSC-DC006612 from Creative biogene Category Cell Line Species Human

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