GPS1

Gene Symbol GPS1
Entrez Gene 2873
Alt Symbol COPS1, CSN1
Species Human
Gene Type protein-coding
Description G protein pathway suppressor 1
Other Description COP9 signalosome complex subunit 1|COP9 signalosome subunit 1|GPS-1|JAB1-containing signalosome subunit 1|SGN1|signalosome subunit 1
Swissprots Q8NA10 Q9BWL1 Q13098
Accessions EAW89741 EAW89742 Q13098 AB209596 BAD92833 AK026610 AK093283 BAC04120 AK222508 AK225248 AK289435 BAF82124 AK297872 BAG60198 BC000155 AAH00155 BC064503 AAH64503 BG775520 BT009834 AAP88836 EU832312 ACE87569 EU832397 ACE86882 HQ258557 ADR83311 U20285 AAC50906 XM_005256350 XP_005256407 XM_005256351 XP_005256408 XM_005256353 XP_005256410 XM_005256354 XP_005256411 XM_005256357 XP_005256414 XM_005256358 XP_005256415 XM_005256359 XP_005256416 XM_005256360 XP_005256417 XM_005256362 XP_005256419 XM_005256363 XP_005256420 XM_011523563 XP_011521865 XM_011523564 XP_011521866 XM_011523565 XP_011521867 XM_011523566 XP_011521868 XM_011523567 XP_011521869 XM_011523568 XP_011521870 XM_011523569 XP_011521871 XM_011523570 XP_011521872 NM_004127 NP_004118 NM_212492 NP_997657
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:8943324}.

CSN1 CRISPR/Cas9 KO Plasmid (h) - sc-404934 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN1 HDR Plasmid (h) - sc-404934-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN1 Double Nickase Plasmid (h) - sc-404934-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN1 Double Nickase Plasmid (h2) - sc-404934-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN1 CRISPR Activation Plasmid (h) - sc-404934-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN1 CRISPR Activation Plasmid (h2) - sc-404934-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN1 Lentiviral Activation Particles (h) - sc-404934-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN1 Lentiviral Activation Particles (h2) - sc-404934-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN1 siRNA (h) - sc-60455 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN1 shRNA Plasmid (h) - sc-60455-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN1 shRNA (h) Lentiviral Particles - sc-60455-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN1 RNAi - H00002873-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CSN1 RNAi - H00002873-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU085041 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9638 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9638 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02143 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02143

GPS1 siRNA (Human) - CRH1930 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GPS1 - MBS8225875 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GPS1 (NM_004127.4) - SHH307278 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human GPS1(NM_212492.1) - SHH101891 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human GPS1(NM_004127.4) - SHH101909 from Creative biogene

Category siRNA
Species Reactivities Human

Human GPS1 siRNA - orb262432 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GPS1 shRNA Plasmid (Human) - CHH1930 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GPS1 miRNA 3'UTR clone - MiUTR1H-04240 from Creative biogene

Species Reactivities Human
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