GPS1

Gene Symbol	GPS1
Entrez Gene	2873
Alt Symbol	COPS1, CSN1
Species	Human
Gene Type	protein-coding
Description	G protein pathway suppressor 1
Other Description	COP9 signalosome complex subunit 1|COP9 signalosome subunit 1|GPS-1|JAB1-containing signalosome subunit 1|SGN1|signalosome subunit 1
Swissprots	Q8NA10 Q9BWL1 Q13098
Accessions	EAW89741 EAW89742 Q13098 AB209596 BAD92833 AK026610 AK093283 BAC04120 AK222508 AK225248 AK289435 BAF82124 AK297872 BAG60198 BC000155 AAH00155 BC064503 AAH64503 BG775520 BT009834 AAP88836 EU832312 ACE87569 EU832397 ACE86882 HQ258557 ADR83311 U20285 AAC50906 XM_005256350 XP_005256407 XM_005256351 XP_005256408 XM_005256353 XP_005256410 XM_005256354 XP_005256411 XM_005256357 XP_005256414 XM_005256358 XP_005256415 XM_005256359 XP_005256416 XM_005256360 XP_005256417 XM_005256362 XP_005256419 XM_005256363 XP_005256420 XM_011523563 XP_011521865 XM_011523564 XP_011521866 XM_011523565 XP_011521867 XM_011523566 XP_011521868 XM_011523567 XP_011521869 XM_011523568 XP_011521870 XM_011523569 XP_011521871 XM_011523570 XP_011521872 NM_004127 NP_004118 NM_212492 NP_997657
Function	Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:8943324}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CSN1 peptide - ab23045 from Abcam Category Peptide Species Human

Human CSN1 protein fragment - ab132037 from Abcam Category Protein Source Wheat germ Species Human

Human CSN1 protein fragment - ab158574 from Abcam Category Protein Source Wheat germ Species Human

GPS1 / CSN1 Antibody Blocking Peptide - LS-E1876 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GPS1 / CSN1 Antibody Blocking Peptide - LS-E25543 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GPS1 / CSN1 Antibody Blocking Peptide - LS-E21215 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GPS1 / CSN1 Antibody Blocking Peptide - LS-E21216 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CSN1 Protein - H00002873-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CSN1 Protein - H00002873-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GPS1-Antibody-Center-Blocking-peptide - BP12706c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GPS1 Immunizing peptide - orb17757 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

GPS1 Blocking Peptide - 33R-7203 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CSN1 Peptide - AC21-0372-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

GPS1 / COPS / CSN1 - H00002873-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GPS1 / COPS / CSN1 - H00002873-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GPS1 / COPS / CSN1 - H00002873-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GPS1 / COPS / CSN1 - H00002873-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GPS1 Peptide - 45-697P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

GPS1 fusion protein - ag2273 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human COP9 signalosome complex subunit 1(GPS1) - CSB-YP615663HU CSB-EP615663HU CSB-BP615663HU CSB-MP615663HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GPS1 / COPS / CSN1 (transcript variant 1) - TP309147 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

GPS1/COPS1, Peptide - MBS426460 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

CSN1 Blocking Peptide (OESA09437) - OESA09437 from Aviva Systems Biology Category Peptide Prices $200.00 Sizes 50 µg

GPS1 Peptide, Human - M34GP06612H from Creative Peptides Category Peptide Source Synthetic. Species Human

COP9 signalosome complex subunit 1 (csn-1), Recombinant Protein - MBS1466838 from MyBioSource Category Protein Prices $1,200.00, $1,200.00, $1,420.00, $1,420.00, $1,940.00, $1,940.00, $2,400.00, $2,400.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Neurospora crassa

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