PVRL3

Gene Symbol PVRL3
Entrez Gene 25945
Alt Symbol CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRR3
Species Human
Gene Type protein-coding
Description poliovirus receptor-related 3
Other Description nectin 3|nectin-3|poliovirus receptor-related protein 3
Swissprots Q9BVA9 Q8WVU4 Q6NVZ3 E9PFR0 Q9NQS3 Q8NC05 Q9Y412
Accessions CAD35242 CCF77054 EAW79703 Q9NQS3 AA555086 AF282874 AAF97597 AK075105 BAC11404 AL050071 CAB43256 BC001336 AAH01336 BC017572 AAH17572 BC067808 AAH67808 BI464010 BQ025085 XM_005247322 XP_005247379 XM_011512662 XP_011510964 XM_011512663 XP_011510965 XM_011512664 XP_011510966 XM_011512665 XP_011510967 XM_011512666 XP_011510968 XM_011512667 XP_011510969 XR_924122 NM_001243286 NP_001230215 NM_001243288 NP_001230217 NM_015480 NP_056295
Function Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269|PubMed:16216929}.
Subcellular Location Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
Tissue Specificity Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. {ECO:0000269|PubMed:11024295}.
Top Pathways Adherens junction, Cell adhesion molecules (CAMs)

Nectin 3 (C-19) - sc-14806 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Nectin 3 (C-19): sc-14806. Immunoperoxidase staining of formalin fixed, paraffin-embedded human thyroid gland tissue showing cytoplasmic staining of glandular cells.

Nectin 3 (H-11) - sc-271611 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Nectin 3 (H-11): sc-271611. Western blot analysis of Nectin 3 expression in 3T3-L1 whole cell lysate.

Nectin 3 (K-20) - sc-14805 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Nectin 3 (N3.2.9) - sc-69714 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Nectin 3 expression in HeLa whole cell lysate immunoprecipitated with Nectin 3 (N3.2.9): sc-69714 and detected with Nectin 3 (H-245): sc-28637.

Nectin 3 (N3.12.4) - sc-69715 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Nectin 3 (H-245) - sc-28637 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Nectin 3 expression in HeLa whole cell lysate immunoprecipitated with Nectin 3 (N3.82.5): sc-69717 and detected with Nectin 3 (H-245): sc-28637.

Nectin 3 (N3.81.6) - sc-69716 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Nectin 3 expression in HeLa whole cell lysate immunoprecipitated with Nectin 3 (N3.81.6): sc-69716 and detected with Nectin 3 (H-245): sc-28637.

Anti-Nectin 3 antibody - ab168266 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Nectin 3 antibody (ab168266) at 1 µg/mlLane 1 : Nectin 3 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-Nectin 3 antibody - ab137961 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Nectin 3 antibody (ab137961) at 1/500 dilution + HUVEC cell lysate at 30 µg

Anti-Nectin 3 antibody - ab98342 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Nectin 3 antibody (ab98342) at 1 µg/ml + HT1080 cell lysate at 10 µg

Anti-PVRL3 / Nectin-3 Antibody (aa50-400) - LS-C37482 from LifeSpan Bioscience

Prices $695.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-PVRL3 / Nectin-3 Antibody (aa56-400, Biotin) - LS-C73207 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-PVRL3 / Nectin-3 Antibody (Extracellular Domain, clone 103-A1) - LS-C124231 from LifeSpan Bioscience

Prices $935.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 103-A1

Anti-PVRL3 / Nectin-3 Antibody - LS-C48736 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of PVRL3 / Nectin-3 antibody LS-C48736.

Anti-PVRL3 / Nectin-3 Antibody (Extracellular Domain, clone 103-A1) - LS-C139891 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 103-A1

Anti-PVRL3 / Nectin-3 Antibody (aa50-400, clone 13A62, FITC) - LS-C183001 from LifeSpan Bioscience

Prices $785.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 13A62

Anti-PVRL3 / Nectin-3 Antibody (aa467-516) - LS-C116209 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PVRL3 / Nectin 3 antibody LS-C116209 Western blot of HeLa lysate.

Anti-PVRL3 / Nectin-3 Antibody (aa143-192) - LS-C107780 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PVRL3 / Nectin 3 antibody LS-C107780 Western blot of HT1080 cell lysate.

Anti-PVRL3 / Nectin-3 Antibody (aa536) - LS-C190231 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PVRL3 / Nectin-3 Antibody (clone 103-A1) - LS-C202251 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 103-A1

Anti-PVRL3 / Nectin-3 Antibody (aa50-400, clone 103-A1, FITC) - LS-C210246 from LifeSpan Bioscience

Prices $675.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 103-A1

Anti-PVRL3 / Nectin-3 Antibody (aa514-544, AP) - LS-C267613 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PVRL3 / Nectin-3 Antibody (clone 1D1) - LS-C134055 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D1
Detection limit for recombinant GST tagged PVRL3 is 0.3 ng/ml as a capture antibody.

Anti-PVRL3 / Nectin-3 Antibody (aa514-544, Biotin) - LS-C267614 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PVRL3 / Nectin-3 Antibody (aa514-544, APC) - LS-C267615 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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