PVRL3
| Gene Symbol | PVRL3 |
|---|---|
| Entrez Gene | 25945 |
| Alt Symbol | CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRR3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | poliovirus receptor-related 3 |
| Other Description | nectin 3|nectin-3|poliovirus receptor-related protein 3 |
| Swissprots | Q9BVA9 Q8WVU4 Q6NVZ3 E9PFR0 Q9NQS3 Q8NC05 Q9Y412 |
| Accessions | CAD35242 CCF77054 EAW79703 Q9NQS3 AA555086 AF282874 AAF97597 AK075105 BAC11404 AL050071 CAB43256 BC001336 AAH01336 BC017572 AAH17572 BC067808 AAH67808 BI464010 BQ025085 XM_005247322 XP_005247379 XM_011512662 XP_011510964 XM_011512663 XP_011510965 XM_011512664 XP_011510966 XM_011512665 XP_011510967 XM_011512666 XP_011510968 XM_011512667 XP_011510969 XR_924122 NM_001243286 NP_001230215 NM_001243288 NP_001230217 NM_015480 NP_056295 |
| Function | Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269|PubMed:16216929}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. |
| Tissue Specificity | Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. {ECO:0000269|PubMed:11024295}. |
| Top Pathways | Adherens junction, Cell adhesion molecules (CAMs) |
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