PVRL3

Gene Symbol PVRL3
Entrez Gene 25945
Alt Symbol CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRR3
Species Human
Gene Type protein-coding
Description poliovirus receptor-related 3
Other Description nectin 3|nectin-3|poliovirus receptor-related protein 3
Swissprots Q9BVA9 Q8WVU4 Q6NVZ3 E9PFR0 Q9NQS3 Q8NC05 Q9Y412
Accessions CAD35242 CCF77054 EAW79703 Q9NQS3 AA555086 AF282874 AAF97597 AK075105 BAC11404 AL050071 CAB43256 BC001336 AAH01336 BC017572 AAH17572 BC067808 AAH67808 BI464010 BQ025085 XM_005247322 XP_005247379 XM_011512662 XP_011510964 XM_011512663 XP_011510965 XM_011512664 XP_011510966 XM_011512665 XP_011510967 XM_011512666 XP_011510968 XM_011512667 XP_011510969 XR_924122 NM_001243286 NP_001230215 NM_001243288 NP_001230217 NM_015480 NP_056295
Function Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269|PubMed:16216929}.
Subcellular Location Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
Tissue Specificity Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. {ECO:0000269|PubMed:11024295}.
Top Pathways Adherens junction, Cell adhesion molecules (CAMs)

Proline-rich protein 3 (PRR3), Human, ELISA Kit - E01P0868 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Poliovirus Receptor Related Protein 3, PVRL3, Mouse, ELISA Kit - E-EL-M0936 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Human PVRL3 ELISA Kit - HP0755 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Anserine PVRL3 ELISA Kit - AP0755 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Poliovirus Receptor Related Protein 3 (PVRL3) - MBS728488 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00
Sizes 48 strip wells, 96 strip wells

Poliovirus Receptor Related Protein 3 (PVRL3) - MBS732865 from MyBioSource

Category ELISA Kit

Poliovirus Receptor Related Protein 3 (PVRL3) - MBS729289 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00
Sizes 48 strip wells, 96 strip wells

Poliovirus Receptor Related Protein 3 (PVRL3) - MBS726230 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00
Sizes 48 strip wells, 96 strip wells

Poliovirus Receptor Related Protein 3 (PVRL3) - MBS724215 from MyBioSource

Category ELISA Kit

PVRL3, ELISA Kit - MBS2504814 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.094ng/mL
Range 0.156-10ng/mL

Custom Human Nectin-3 ELISA - ELH-NEC3 from RayBiotech

Category ELISA Kit
Prices $615.00, $1,107.00, $2,460.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Nectin-3 ELISA - RAB1588 from Sigma-Aldrich

Prices $615.00
Sizes 1 kt

Custom Human Nectin-3 ELISA - ELH-NEC3-1 from RayBiotech

Category ELISA Kit
Prices $627.00, $1,128.60, $2,508.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human PVRL3 ELISA Kit - E029981 from Biobool

Category ELISA Kit

Human PRR3 ELISA Kit - E031126 from Biobool

Category ELISA Kit

Human PVRL3 ELISA Kit - EHP0755 from ABclonal

Category ELISA Kit
Prices $495.00
Sizes 96 t
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