UPF3B

Gene Symbol	UPF3B
Entrez Gene	65109
Alt Symbol	HUPF3B, MRX62, MRXS14, RENT3B, UPF3X
Species	Human
Gene Type	protein-coding
Description	UPF3 regulator of nonsense transcripts homolog B (yeast)
Other Description	hUpf3p-X|mental retardation, X-linked 62|nonsense mRNA reducing factor 3B|regulator of nonsense transcripts 3B|up-frameshift suppressor 3 homolog B|up-frameshift suppressor 3 homolog on chromosome X
Swissprots	Q9H1J0 Q0VAK8 D3DWI3 Q9BZI7 D3DWI4
Accessions	AFL55650 EAW89842 EAW89843 EAW89844 EAW89845 EAW89846 Q9BZI7 AF318576 AAG60691 AK093728 BAG52755 AY013251 AAG48511 BC008494 BC121017 AAI21018 BC121018 AAI21019 BF223724 BI549935 CN412717 DA949746 EG328250 XM_005262458 XP_005262515 XM_006724780 XP_006724843 XM_006724781 XP_006724844 XM_011531378 XP_011529680 XM_011531379 XP_011529681 NM_023010 NP_075386 NM_080632 NP_542199
Function	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}.
Subcellular Location	Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
Tissue Specificity	Expressed in testis, uterus, prostate, heart, muscle, brain, spinal cord and placenta. {ECO:0000269|PubMed:11113196}.
Top Pathways	RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UPF3B/RENT3B peptide - ab45333 from Abcam Category Peptide

Human UPF3B/RENT3B peptide - ab45334 from Abcam Category Peptide

UPF3B Antibody Blocking Peptide - LS-E15083 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UPF3B Blocking Peptide - 33R-6132 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UPF3B Blocking Peptide - 33R-4426 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UPF3B fusion protein - ag18568 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

UPF3B fusion protein - ag18667 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human UPF3B, His-tagged - UPF3B-31673TH from Creative Biomart Category Protein Source E. coli

Recombinant Human Regulator of nonsense transcripts 3B(UPF3B) - CSB-YP883646HU CSB-EP883646HU CSB-BP883646HU CSB-MP883646HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

UPF3B / RENT3B (transcript variant 2) - TP321828 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

UPF3B Recombinant Protein Antigen - NBP1-83135PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

UPF3B Recombinant Protein Antigen - NBP1-83134PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

UPF3B-Antibody-Center-Blocking-Peptide - BP9653c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UPF3B Peptide, Human - M34GP17108H from Creative Peptides Category Peptide Source Synthetic. Species Human

Regulator of nonsense transcripts 3B (UPF3B), Recombinant Protein - MBS1343065 from MyBioSource Category Protein Prices $1,265.00, $1,265.00, $1,485.00, $1,485.00, $2,075.00, $2,075.00, $2,540.00, $2,540.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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