| Gene Symbol |
BMP8A
|
| Entrez Gene |
353500
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
bone morphogenetic protein 8a
|
| Other Description |
BMP-8A|bone morphogenetic protein 8A
|
| Swissprots |
Q5T3A5 Q7Z5Y6
|
| Accessions |
EAX07272 EAX07273 Q7Z5Y6 AA732526 AK024413 BAB14915 AK127199 BAC86882 AY303954 AAP74559 BC093743 AAH93743 BC112044 BC131617 AAI31618 BU616301 XM_006710616 XP_006710679 XM_011541381 XP_011539683 XM_011541382 XP_011539684 XR_946640 XR_946641 XR_946642 NM_181809 NP_861525
|
| Function |
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT. {ECO:0000250, ECO:0000269|PubMed:22579288}.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
| Top Pathways |
TGF-beta signaling pathway, Hippo signaling pathway
|
![Western Blot: BMP8a Overexpression Lysate (Adult Normal) [NBP2-04885] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BMP8a.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/7529_BMP8a%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-04885-img0001.jpg)