Gene Symbol | BMP8A |
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Entrez Gene | 353500 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | bone morphogenetic protein 8a |
Other Description | BMP-8A|bone morphogenetic protein 8A |
Swissprots | Q5T3A5 Q7Z5Y6 |
Accessions | EAX07272 EAX07273 Q7Z5Y6 AA732526 AK024413 BAB14915 AK127199 BAC86882 AY303954 AAP74559 BC093743 AAH93743 BC112044 BC131617 AAI31618 BU616301 XM_006710616 XP_006710679 XM_011541381 XP_011539683 XM_011541382 XP_011539684 XR_946640 XR_946641 XR_946642 NM_181809 NP_861525 |
Function | Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT. {ECO:0000250, ECO:0000269|PubMed:22579288}. |
Subcellular Location | Secreted {ECO:0000305}. |
Top Pathways | TGF-beta signaling pathway, Hippo signaling pathway |
BMP-8A CRISPR/Cas9 KO Plasmid (h) - sc-406589 from Santa Cruz Biotechnology
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BMP-8A HDR Plasmid (h) - sc-406589-HDR from Santa Cruz Biotechnology
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BMP-8A Double Nickase Plasmid (h) - sc-406589-NIC from Santa Cruz Biotechnology
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BMP-8A Double Nickase Plasmid (h2) - sc-406589-NIC-2 from Santa Cruz Biotechnology
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BMP-8A CRISPR Activation Plasmid (h) - sc-406589-ACT from Santa Cruz Biotechnology
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BMP-8A CRISPR Activation Plasmid (h2) - sc-406589-ACT-2 from Santa Cruz Biotechnology
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BMP-8A Lentiviral Activation Particles (h) - sc-406589-LAC from Santa Cruz Biotechnology
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BMP-8A Lentiviral Activation Particles (h2) - sc-406589-LAC-2 from Santa Cruz Biotechnology
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BMP-8A siRNA (h) - sc-39752 from Santa Cruz Biotechnology
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BMP-8A shRNA Plasmid (h) - sc-39752-SH from Santa Cruz Biotechnology
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BMP-8A shRNA (h) Lentiviral Particles - sc-39752-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU109661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4007 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4007 from Sigma-Aldrich
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BMP8A siRNA (Human) - CRJ7592 from Cohesion Biosciences
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BMP8A - MBS8215411 from MyBioSource
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BMP-8A CRISPR/Cas9 KO Plasmid (h2) - sc-406589-KO-2 from Santa Cruz Biotechnology
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BMP-8A HDR Plasmid (h2) - sc-406589-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Bmp8a (NM_181809.3) - SHH247122 from Creative biogene
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Human BMP8A siRNA - orb278093 from Biorbyt
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BMP8A shRNA Plasmid (Human) - CHJ7592 from Cohesion Biosciences
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BMP8A miRNA 3'UTR clone - MiUTR1H-00916 from Creative biogene
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