| Gene Symbol |
PAIP1
|
| Entrez Gene |
10605
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
poly(A) binding protein interacting protein 1
|
| Other Description |
PABC1-interacting protein 1|PABP-interacting protein 1|PAIP-1|poly(A)-binding protein-interacting protein 1|polyadenylate binding protein-interacting protein 1|polyadenylate-binding protein-interacting protein 1
|
| Swissprots |
Q9BS63 O60455 A6NKV8 Q9H074 Q96B61
|
| Accessions |
EAW56067 EAW56068 EAW56069 EAW56070 Q9H074 AF013758 AAC39697 AK308270 AL136920 CAB66854 BC005295 AAH05295 BC015937 AAH15937 BG430290 BG719757 DB089732 DQ786248 DQ786326 DQ891110 ABM82036 EU176558 ABW03359 XM_005248230 XP_005248287 XM_011513938 XP_011512240 NM_006451 NP_006442 NM_182789 NP_877590 NM_183323 NP_899152
|
| Function |
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:9548260}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}.
|
| Top Pathways |
RNA transport
|