Gene Symbol | PAIP1 |
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Entrez Gene | 10605 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | poly(A) binding protein interacting protein 1 |
Other Description | PABC1-interacting protein 1|PABP-interacting protein 1|PAIP-1|poly(A)-binding protein-interacting protein 1|polyadenylate binding protein-interacting protein 1|polyadenylate-binding protein-interacting protein 1 |
Swissprots | Q9BS63 O60455 A6NKV8 Q9H074 Q96B61 |
Accessions | EAW56067 EAW56068 EAW56069 EAW56070 Q9H074 AF013758 AAC39697 AK308270 AL136920 CAB66854 BC005295 AAH05295 BC015937 AAH15937 BG430290 BG719757 DB089732 DQ786248 DQ786326 DQ891110 ABM82036 EU176558 ABW03359 XM_005248230 XP_005248287 XM_011513938 XP_011512240 NM_006451 NP_006442 NM_182789 NP_877590 NM_183323 NP_899152 |
Function | Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:9548260}. |
Subcellular Location | Cytoplasm {ECO:0000305}. |
Top Pathways | RNA transport |
Paip1 (E-7) - sc-365687 from Santa Cruz Biotechnology
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Paip1 (E-20) - sc-18614 from Santa Cruz Biotechnology
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Paip1 (F-6) - sc-365188 from Santa Cruz Biotechnology
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Paip1 (H-300) - sc-50364 from Santa Cruz Biotechnology
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Anti-PAIP1 antibody - ab92859 from Abcam
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Anti-PAIP1 antibody [EPR13258(B)] - ab175211 from Abcam
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Anti-PAIP1 antibody [EPR13259] - ab181359 from Abcam
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Anti-PAIP1 antibody - N-terminal - ab200157 from Abcam
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Anti-PAIP1 antibody - N-terminal - ab138851 from Abcam
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Anti-PAIP1 Antibody (aa23-49, AP) - LS-C265504 from LifeSpan Bioscience
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Anti-PAIP1 Antibody (aa23-49, APC) - LS-C265505 from LifeSpan Bioscience
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Anti-PAIP1 Antibody (aa23-49, Biotin) - LS-C265506 from LifeSpan Bioscience
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Anti-PAIP1 Antibody (aa23-49, FITC) - LS-C265507 from LifeSpan Bioscience
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Anti-PAIP1 Antibody (aa23-49, Azide-free, HRP) - LS-C265508 from LifeSpan Bioscience
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Anti-PAIP1 Antibody (aa23-49, PE) - LS-C265509 from LifeSpan Bioscience
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Anti-PAIP1 Antibody (aa23-49) - LS-C323761 from LifeSpan Bioscience
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Anti-PAIP1 Antibody - LS-C155421 from LifeSpan Bioscience
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Anti-PAIP1 Antibody (N-Terminus) - LS-C80362 from LifeSpan Bioscience
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Anti-PAIP1 Antibody (aa23-49) - LS-C158525 from LifeSpan Bioscience
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Anti-PAIP1 Antibody - LS-C334484 from LifeSpan Bioscience
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Anti-PAIP1 Antibody (aa322-371) - LS-C31607 from LifeSpan Bioscience
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Anti-PAIP1 Antibody (clone 2D11) - LS-C139265 from LifeSpan Bioscience
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PAIP1 Antibody - NBP1-57310 from Novus Biologicals
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PAIP1 Antibody - NBP1-57494 from Novus Biologicals
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PAIP1 Antibody - NBP2-19679 from Novus Biologicals
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