| Gene Symbol |
SRSF9
|
| Entrez Gene |
8683
|
| Alt Symbol |
SFRS9, SRp30c
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine/arginine-rich splicing factor 9
|
| Other Description |
SR splicing factor 9|pre-mRNA-splicing factor SRp30C|splicing factor, arginine/serine-rich 9
|
| Swissprots |
Q52LD1 Q13242
|
| Accessions |
AAD00626 EAW98194 Q13242 AA845918 AI005398 AK290644 BAF83333 AK294254 BAG57550 AK309778 BC093971 AAH93971 BC093973 AAH93973 BU786332 U30825 AAA93069 NM_003769 NP_003760
|
| Function |
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11694584, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611}. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells.
|
| Tissue Specificity |
Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle. {ECO:0000269|PubMed:10196175}.
|
| Top Pathways |
Spliceosome, Herpes simplex infection
|