| Gene Symbol | SRSF9 |
|---|---|
| Entrez Gene | 8683 |
| Alt Symbol | SFRS9, SRp30c |
| Species | Human |
| Gene Type | protein-coding |
| Description | serine/arginine-rich splicing factor 9 |
| Other Description | SR splicing factor 9|pre-mRNA-splicing factor SRp30C|splicing factor, arginine/serine-rich 9 |
| Swissprots | Q52LD1 Q13242 |
| Accessions | AAD00626 EAW98194 Q13242 AA845918 AI005398 AK290644 BAF83333 AK294254 BAG57550 AK309778 BC093971 AAH93971 BC093973 AAH93973 BU786332 U30825 AAA93069 NM_003769 NP_003760 |
| Function | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11694584, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611}. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells. |
| Tissue Specificity | Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle. {ECO:0000269|PubMed:10196175}. |
| Top Pathways | Spliceosome, Herpes simplex infection |
SRp30c CRISPR/Cas9 KO Plasmid (h) - sc-403790 from Santa Cruz Biotechnology
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SRp30c HDR Plasmid (h) - sc-403790-HDR from Santa Cruz Biotechnology
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SRp30c Double Nickase Plasmid (h) - sc-403790-NIC from Santa Cruz Biotechnology
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SRp30c Double Nickase Plasmid (h2) - sc-403790-NIC-2 from Santa Cruz Biotechnology
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SRp30c CRISPR Activation Plasmid (h) - sc-403790-ACT from Santa Cruz Biotechnology
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SRp30c CRISPR Activation Plasmid (h2) - sc-403790-ACT-2 from Santa Cruz Biotechnology
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SRp30c Lentiviral Activation Particles (h) - sc-403790-LAC from Santa Cruz Biotechnology
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SRp30c Lentiviral Activation Particles (h2) - sc-403790-LAC-2 from Santa Cruz Biotechnology
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SRp30c siRNA (h) - sc-95734 from Santa Cruz Biotechnology
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SRp30c shRNA Plasmid (h) - sc-95734-SH from Santa Cruz Biotechnology
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SRp30c shRNA (h) Lentiviral Particles - sc-95734-V from Santa Cruz Biotechnology
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SFRS9 RNAi - H00008683-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN20608 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20608 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02737 from Sigma-Aldrich
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SRSF9 siRNA (Human) - CRH5714 from Cohesion Biosciences
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SRSF9 - MBS8205958 from MyBioSource
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shRNA set against Human SRSF9 (NM_003769.2) - SHH418276 from Creative biogene
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shRNA set against Human SFRS9(NM_003769.2) - SHR220614 from Creative biogene
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SRp30c CRISPR/Cas9 KO Plasmid (h2) - sc-403790-KO-2 from Santa Cruz Biotechnology
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SRp30c HDR Plasmid (h2) - sc-403790-HDR-2 from Santa Cruz Biotechnology
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SRSF9 shRNA Plasmid (Human) - CHH5714 from Cohesion Biosciences
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SRSF9 miRNA 3'UTR clone - MiUTR1H-09337 from Creative biogene
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