| Gene Symbol |
LGR6
|
| Entrez Gene |
59352
|
| Alt Symbol |
GPCR, VTS20631
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine-rich repeat containing G protein-coupled receptor 6
|
| Other Description |
gonadotropin receptor|leucine-rich repeat-containing G protein-coupled receptor 6|leucine-rich repeat-containing G-protein coupled receptor 6
|
| Swissprots |
Q96K69 Q6UY15 Q5T512 Q5T509 Q86VU0 Q9BYD7 Q9HBX8
|
| Accessions |
BAB89329 CAH05693 EAW91407 EAW91408 EAW91409 EAW91410 Q9HBX8 AB049405 BAB39854 AF088074 AF190501 AAG17168 AK027377 BAB55071 AK123055 AY358119 AAQ88486 BC038795 BC047905 AAH47905 BM699180 XM_005245404 XP_005245461 XM_011509838 XP_011508140 XM_011509839 XP_011508141 XM_011509840 XP_011508142 XM_011509841 XP_011508143 XM_011509842 XP_011508144 XM_011509843 XP_011508145 XM_011509844 XP_011508146 XM_011509845 XP_011508147 XM_011509846 XP_011508148 NM_001017403 NP_001017403 NM_001017404 NP_001017404 NM_021636 NP_067649
|
| Function |
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:22615920}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22615920}; Multi-pass membrane protein {ECO:0000269|PubMed:22615920}.
|