LGR6

Gene Symbol	LGR6
Entrez Gene	59352
Alt Symbol	GPCR, VTS20631
Species	Human
Gene Type	protein-coding
Description	leucine-rich repeat containing G protein-coupled receptor 6
Other Description	gonadotropin receptor|leucine-rich repeat-containing G protein-coupled receptor 6|leucine-rich repeat-containing G-protein coupled receptor 6
Swissprots	Q96K69 Q6UY15 Q5T512 Q5T509 Q86VU0 Q9BYD7 Q9HBX8
Accessions	BAB89329 CAH05693 EAW91407 EAW91408 EAW91409 EAW91410 Q9HBX8 AB049405 BAB39854 AF088074 AF190501 AAG17168 AK027377 BAB55071 AK123055 AY358119 AAQ88486 BC038795 BC047905 AAH47905 BM699180 XM_005245404 XP_005245461 XM_011509838 XP_011508140 XM_011509839 XP_011508141 XM_011509840 XP_011508142 XM_011509841 XP_011508143 XM_011509842 XP_011508144 XM_011509843 XP_011508145 XM_011509844 XP_011508146 XM_011509845 XP_011508147 XM_011509846 XP_011508148 NM_001017403 NP_001017403 NM_001017404 NP_001017404 NM_021636 NP_067649
Function	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:22615920}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:22615920}; Multi-pass membrane protein {ECO:0000269|PubMed:22615920}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GPCR LGR6 full length protein - ab153472 from Abcam Category Protein Source Wheat germ Species Human

Human GPCR LGR6 protein fragment - ab153473 from Abcam Category Protein Source Wheat germ Species Human

LGR6 Antibody Blocking Peptide - LS-E28958 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

LGR6 Antibody Blocking Peptide - LS-E29117 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Lgr6 Protein - H00059352-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Lgr6 Protein - H00059352-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Lgr6 Blocking Peptide - NBP1-49695PEP from Novus Biologicals Category Peptide Prices $229.00 Sizes 250 µg Species Human

Lgr6 Recombinant Protein - H00059352-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

Recombinant Mouse Lgr6 Fc Chimera, CF - 8029-GP-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

GPR6 / LGR6 - H00059352-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

GPR6 / LGR6 - H00059352-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

GPR6 / LGR6 - H00059352-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

GPR6 / LGR6 - H00059352-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GPR6 / LGR6 - H00059352-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LGR6 fusion protein - Ag11924 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

LGR6 fusion protein - ag11909 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human LGR6, His-tagged - LGR6-559H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Mouse Lgr6 Fc Chimera Protein, CF - 8029-GP from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Mouse Lgr6 (Gly23-Ala567) Accession # Q3UVD5 IEGRMDP Mouse IgG 2A (Glu98-Lys330) N-terminus C-terminus Species Mouse

LGR6 Blocking Peptide - abx161662 from Abbexa Category Peptide Species Human

LGR6 Protein - abx163869 from Abbexa Category Protein Species Human

Recombinant Human Lgr6 Fc Chimera Protein, CF - 8470-GP from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Human Lgr6 (Ala25-Ala567) Accession # Q9HBX8 IEGRMD Human IgG 1 (Pro100-Lys330) N-terminus C-terminus Species Human

Lgr6 Protein - NBP2-33864PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

LGR6 Peptide, Human - M34GP08675H from Creative Peptides Category Peptide Source Synthetic. Species Human

LGR6 Blocking Peptide - CBP4451 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

LGR6 Blocking Peptide - orb392796 from Biorbyt Category Peptide Prices $238.00, $476.00 Sizes 1 mg, 5 mg Species Human

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