LGR6

Gene Symbol LGR6
Entrez Gene 59352
Alt Symbol GPCR, VTS20631
Species Human
Gene Type protein-coding
Description leucine-rich repeat containing G protein-coupled receptor 6
Other Description gonadotropin receptor|leucine-rich repeat-containing G protein-coupled receptor 6|leucine-rich repeat-containing G-protein coupled receptor 6
Swissprots Q96K69 Q6UY15 Q5T512 Q5T509 Q86VU0 Q9BYD7 Q9HBX8
Accessions BAB89329 CAH05693 EAW91407 EAW91408 EAW91409 EAW91410 Q9HBX8 AB049405 BAB39854 AF088074 AF190501 AAG17168 AK027377 BAB55071 AK123055 AY358119 AAQ88486 BC038795 BC047905 AAH47905 BM699180 XM_005245404 XP_005245461 XM_011509838 XP_011508140 XM_011509839 XP_011508141 XM_011509840 XP_011508142 XM_011509841 XP_011508143 XM_011509842 XP_011508144 XM_011509843 XP_011508145 XM_011509844 XP_011508146 XM_011509845 XP_011508147 XM_011509846 XP_011508148 NM_001017403 NP_001017403 NM_001017404 NP_001017404 NM_021636 NP_067649
Function Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:22615920}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:22615920}; Multi-pass membrane protein {ECO:0000269|PubMed:22615920}.

LGR6 (F-5) - sc-393010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LGR6 (F-5): sc-393010. Western blot analysis of LGR6 expression in HUV-EC-C (A) and HeLa (B) whole cell lysates.

LGR6 (H-90) - sc-99123 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LGR6 (H-90): sc-99123. Western blot analysis of LGR6 expression in HeLa (A) and HISM (B) whole cell lysates.

LGR6 (K-17) - sc-48235 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LGR6 (K-18) - sc-48236 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LGR6 (K-18): sc-48236. Western blot analysis of LGR6 expression in non-transfected: sc-117752 (A) and human LGR6 transfected: sc-111380 (B) 293T whole cell lysates.

Anti-GPCR LGR6 antibody - ab75504 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GPCR LGR6 antibody (ab75504) at 1/500 dilutionLane 1 : HUVEC extractLane 2 : HUVEC extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-GPCR LGR6 antibody - ab128257 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GPCR LGR6 antibody - ab140823 from Abcam

Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human neutrophils labelling GPCR LGR6 with ab140823 at 10 ug/ml.

Anti-GPCR LGR6 antibody [2A3] - ab156942 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A3
All lanes : Anti-GPCR LGR6 antibody [2A3] (ab156942) at 1/1000 dilutionLane 1 : HEK293T cells lysateLane 2 : HEK293T cells lysate expressing Human GPCR LGR6 recombinant fragment (amino acids 25-250)Lysates/proteins at 5 µg per lane.

Anti-GPCR LGR6 antibody [EPR6874] - ab126747 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6874
All lanes : Anti-GPCR LGR6 antibody [EPR6874] (ab126747) at 1/1000 dilutionLane 1 : Human uterus lysateLane 2 : Human ovary lysateLane 3 : HUVEC lysateLane 4 : Human adrenal gland lysateLane 5 : HeLa lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-GPCR LGR6 antibody - N-terminal - ab188961 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, neuron, labeling GPCR LGR6 with ab188961 at 4 µg/ml.

Anti-GPCR LGR6 antibody - N-terminal - ab187319 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GPCR LGR6 antibody - N-terminal (ab187319) at 1/1000 dilutionLane 1 : Hela total cell extractLane 2 : Jurkat total cell extract

Anti-LGR6 Antibody - LS-C153479 from LifeSpan Bioscience

Prices $305.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LGR6 Antibody (aa471-520) - LS-C120734 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using LGR6 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-LGR6 Antibody (clone 2A3) - LS-C173950 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A3
Anti-LGR6 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR6.

Anti-LGR6 Antibody (Intracellular Domain, clone EPR6874) IHC-plus™ - LS-B8484 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6874
Anti-LGR6 antibody IHC of human breast epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8484 dilution 1:50-1:100.

Anti-LGR6 Antibody (N-Terminus) IHC-plus™ - LS-A442 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LGR6 antibody LS-A442 IHC of human brain, neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-LGR6 Antibody (Internal) IHC-plus™ - LS-A621 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LGR6 antibody LS-A621 IHC of human neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Lgr6 Antibody - NBP2-33864 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Lgr6 Antibody [NBP2-33864] - LGR6 Antibody [NBP2-33864] - Immunohistochemical staining of human colon shows strong cytoplasmic and membranous positivity in glandular cells.

Lgr6 Antibody - NLS442 from Novus Biologicals

Prices $329.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Lgr6 Antibody [NLS442] - Analysis of anti-LGR6 antibody with human brain, neuron at 2.5 ug/ml.

Lgr6 Antibody - NBP1-49695 from Novus Biologicals

Prices $449.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Lgr6 Antibody - H00059352-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Lgr6 Antibody [FITC] - NBP1-49696 from Novus Biologicals

Host Rabbit
Clonality Polyclonal

LGR6 Polyclonal Antibody - bs-8609R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded mouse kidney tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-LGR6 Polyclonal Antibody, Unconjugated (bs-8609R) at 1:200 overnight at 4°C, followed by a conjugated secondary and DAB staining

Anti-LGR6 antibody produced in rabbit - HPA008556 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LGR6: <B>Cat. No. HPA008556</B>: Immunohistochemical staining of Human colon shows strong cytoplasmic and membranous positivity in glandular cells.
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