| Gene Symbol |
PIP4K2B
|
| Entrez Gene |
8396
|
| Alt Symbol |
PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
|
| Other Description |
1-phosphatidylinositol 5-phosphate 4-kinase 2-beta|1-phosphatidylinositol-4-phosphate kinase|1-phosphatidylinositol-5-phosphate 4-kinase 2-beta|PI(5)P 4-kinase type II beta|PIP4KII-beta|PTDINS(4)P-5-kinase|diphosphoinositide kinase 2-beta|phosphatidylinositol 5-phosphate 4-kinase type II beta|phosphatidylinositol 5-phosphate 4-kinase type-2 beta|phosphatidylinositol-4-phosphate 5-kinase, type II, beta|phosphatidylinositol-5-phosphate 4-kinase type-2 beta|ptdIns(5)P-4-kinase isoform 2-beta
|
| Swissprots |
P78356 Q8TBP2 Q5U0E8
|
| Accessions |
EAW60532 EAW60533 EAW60534 EAW60535 EAW60536 P78356 AI333549 AK307169 BC027459 AAH27459 BC073896 BC094858 BM991982 BT019614 AAV38420 U85245 AAB48596 XM_011525326 XP_011523628 XM_011525327 XP_011523629 XM_011525328 XP_011523630 XM_011525329 XP_011523631 XM_011525330 XP_011523632 XM_011525331 XP_011523633 XM_011546846 XP_011545148 XM_011546847 XP_011545149 XM_011546848 XP_011545150 XM_011546849 XP_011545151 XM_011546850 XP_011545152 XM_011546851 XP_011545153 NM_003559 NP_003550 NM_138687
|
| Function |
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:9038203}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20583997}. Cytoplasm {ECO:0000269|PubMed:20583997}. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. {ECO:0000269|PubMed:9038203}.
|
| Top Pathways |
Inositol phosphate metabolism, Regulation of actin cytoskeleton, Phosphatidylinositol signaling system
|