| Gene Symbol |
C19orf40
|
| Entrez Gene |
91442
|
| Alt Symbol |
FAAP24
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromosome 19 open reading frame 40
|
| Other Description |
Fanconi anemia-associated protein of 24 kDa
|
| Swissprots |
Q8WUJ7 Q96FX6 B3KY46 Q9BTP7
|
| Accessions |
Q9BTP7 AK128668 BAG54708 BC003535 AAH03535 BC010170 AAH10170 BC020247 AAH20247 BM679170 BX390218 CD690094 CN368337 DA006539 HQ447666 ADQ32151 XM_005259393 XP_005259450 NM_001300978 NP_001287907 NM_152266 NP_689479
|
| Function |
Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. {ECO:0000269|PubMed:17289582}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17289582}.
|
| Top Pathways |
Fanconi anemia pathway
|