Gene Symbol | C19orf40 |
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Entrez Gene | 91442 |
Alt Symbol | FAAP24 |
Species | Human |
Gene Type | protein-coding |
Description | chromosome 19 open reading frame 40 |
Other Description | Fanconi anemia-associated protein of 24 kDa |
Swissprots | Q8WUJ7 Q96FX6 B3KY46 Q9BTP7 |
Accessions | Q9BTP7 AK128668 BAG54708 BC003535 AAH03535 BC010170 AAH10170 BC020247 AAH20247 BM679170 BX390218 CD690094 CN368337 DA006539 HQ447666 ADQ32151 XM_005259393 XP_005259450 NM_001300978 NP_001287907 NM_152266 NP_689479 |
Function | Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. {ECO:0000269|PubMed:17289582}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:17289582}. |
Top Pathways | Fanconi anemia pathway |
FAAP24 CRISPR/Cas9 KO Plasmid (h) - sc-408998 from Santa Cruz Biotechnology
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FAAP24 HDR Plasmid (h) - sc-408998-HDR from Santa Cruz Biotechnology
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FAAP24 Double Nickase Plasmid (h) - sc-408998-NIC from Santa Cruz Biotechnology
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FAAP24 Double Nickase Plasmid (h2) - sc-408998-NIC-2 from Santa Cruz Biotechnology
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FAAP24 CRISPR Activation Plasmid (h) - sc-408998-ACT from Santa Cruz Biotechnology
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FAAP24 CRISPR Activation Plasmid (h2) - sc-408998-ACT-2 from Santa Cruz Biotechnology
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FAAP24 Lentiviral Activation Particles (h) - sc-408998-LAC from Santa Cruz Biotechnology
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FAAP24 Lentiviral Activation Particles (h2) - sc-408998-LAC-2 from Santa Cruz Biotechnology
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FAAP24 siRNA (h) - sc-97198 from Santa Cruz Biotechnology
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FAAP24 shRNA Plasmid (h) - sc-97198-SH from Santa Cruz Biotechnology
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FAAP24 shRNA (h) Lentiviral Particles - sc-97198-V from Santa Cruz Biotechnology
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FAAP24 RNAi - H00091442-R01 from Novus Biologicals
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MISSION® esiRNA - EHU002241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4536 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4536 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03741 from Sigma-Aldrich
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FAAP24 siRNA (Human) - CRJ4040 from Cohesion Biosciences
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FAAP24 - MBS8211977 from MyBioSource
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shRNA set against Human C19orf40 (NM_152266.3) - SHH250146 from Creative biogene
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Human FAAP24 siRNA - orb274541 from Biorbyt
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FAAP24 shRNA Plasmid (Human) - CHJ4040 from Cohesion Biosciences
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C19ORF40 miRNA 3'UTR clone - MiUTR3H-11530 from Creative biogene
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