SAP18

Gene Symbol SAP18
Entrez Gene 10284
Alt Symbol 2HOR0202, SAP18P
Species Human
Gene Type protein-coding
Description Sin3A-associated protein, 18kDa
Other Description 18 kDa Sin3-associated polypeptide|cell growth inhibiting protein 38|cell growth-inhibiting gene 38 protein|cell growth-inhibiting protein 38|histone deacetlyase complex subunit SAP18|histone deacetylase complex subunit SAP18|sin3-associated polypeptide p18|sin3-associated polypeptide, 18 kDa|sin3-associated polypeptide, p18
Swissprots Q6IAW9 Q2TTR4 Q8N606 B2R494 O00422 Q9UF14
Accessions EAX08291 O00422 AF153608 AAD41090 AK311748 BAG34691 AY550970 AAT52216 BC030836 AAH30836 BU618473 CR457035 CAG33316 DB171768 EU446760 ABZ92289 U78303 AAF21220 U96915 AAC51322 XM_011534868 XP_011533170 NM_005870 NP_005861
Function Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. In
Subcellular Location Nucleus. Cytoplasm. Nucleus speckle. Note=Shuttles between the nucleus and the cytoplasm. Colocalizes with ACIN1 and SRSF2 in nuclear speckles.
Tissue Specificity Ubiquitous.
Top Pathways RNA transport, mRNA surveillance pathway

SAP 18 (C-3) - sc-365377 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAP 18 (C-3): sc-365377. Western blot analysis of SAP 18 expression in K-562 (A), Jurkat (B) and IMR-32 (C) nuclear extracts.

SAP 18 (E-3) - sc-514365 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAP 18 (E-3): sc-514365. Western blot analysis of SAP 18 expression in K-562 (A) and IMR-32 (B) nuclear extracts.

SAP 18 (C-20) - sc-8473 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SAP 18 (C-20): sc-8473. Immunofluorescence staining of methanol-fixed K-562 cells (A) and immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tumor (B) showing nuclear localization.

SAP 18 (E-4) - sc-365376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAP 18 (E-4): sc-365376. Western blot analysis of SAP 18 expression in K-562 (A), Jurkat (B) and IMR-32 (C) nuclear extracts.

SAP 18 (H-130) - sc-25377 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SAP 18 (H-130): sc-25377. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing nuclear and cytoplasmic staining of urothelial cells.

SAP 18 (N-20) - sc-8472 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SAP 18 (N-20): sc-8472. Western blot analysis of SAP 18 expression in K-562 nuclear extract.

Anti-SAP18 antibody - ab123860 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SAP18 antibody (ab123860) at 1/100 dilution + K562 cell line lysate at 35 µg

Anti-SAP18 antibody - ab56692 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56692 SAP18 antibody at 1ug/ml.

Anti-SAP18 antibody [EPR12956(B)] - ab175920 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12956(B)
All lanes : Anti-SAP18 antibody [EPR12956(B)] (ab175920) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : K562 cell lysateLane 3 : Hela cell lysateLane 4 : 293T cell lysateLane 5 : PC-12 cell lysateLysates/proteins at 10 µg per lane.

Anti-SAP18 Antibody (aa58-86, APC) - LS-C217409 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAP18 Antibody (aa58-86, Biotin) - LS-C217410 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAP18 Antibody (aa58-86, Azide-free, HRP) - LS-C217411 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAP18 Antibody (aa58-86, FITC) - LS-C217412 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAP18 Antibody (aa58-86, PE) - LS-C217413 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAP18 Antibody (aa57-86) - LS-C324908 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAP18 Antibody (aa23-72) - LS-C205640 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SAP18 antibody Western Blot of Fetal Brain. Antibody dilution: 1 ug/ml.

Anti-SAP18 Antibody (aa58-86) - LS-C162864 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SAP18 Antibody western blot of K562 cell line lysates (35 ug/lane). The SAP18 antibody detected the SAP18 protein (arrow).

Anti-SAP18 Antibody (aa30-79) IHC-plus™ - LS-B1561 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SAP18 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1561 concentration 5 ug/ml.

Anti-SAP18 Antibody - LS-C10054 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-SAP18 Antibody (aa58-86, AP) - LS-C217408 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

SAP18 Antibody - NBP1-89385 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: SAP18 Antibody [NBP1-89385] - Staining of human cell line A-431 shows localization to nucleoplasm & nuclear bodies.

SAP18 Antibody - H00010284-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: SAP18 Antibody [H00010284-B01] - SAP18 expression in transfected 293T cell line by SAP18 MaxPab polyclonal antibody (B01). Lane 1: SAP18 transfected lysate (17.60 KDa). Lane 2: Non-transfected lysate.

SAP18 Antibody - H00010284-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

SAP18 Antibody (3B2) - H00010284-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B2
Immunocytochemistry/Immunofluorescence: SAP18 Antibody (3B2) [H00010284-M01] - Analysis of monoclonal antibody to SAP18 on HeLa cell. Antibody concentration 10 ug/ml.

SAP18 Antibody - H00010284-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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