| Gene Symbol |
SAP18
|
| Entrez Gene |
10284
|
| Alt Symbol |
2HOR0202, SAP18P
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Sin3A-associated protein, 18kDa
|
| Other Description |
18 kDa Sin3-associated polypeptide|cell growth inhibiting protein 38|cell growth-inhibiting gene 38 protein|cell growth-inhibiting protein 38|histone deacetlyase complex subunit SAP18|histone deacetylase complex subunit SAP18|sin3-associated polypeptide p18|sin3-associated polypeptide, 18 kDa|sin3-associated polypeptide, p18
|
| Swissprots |
Q6IAW9 Q2TTR4 Q8N606 B2R494 O00422 Q9UF14
|
| Accessions |
EAX08291 O00422 AF153608 AAD41090 AK311748 BAG34691 AY550970 AAT52216 BC030836 AAH30836 BU618473 CR457035 CAG33316 DB171768 EU446760 ABZ92289 U78303 AAF21220 U96915 AAC51322 XM_011534868 XP_011533170 NM_005870 NP_005861
|
| Function |
Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. In
|
| Subcellular Location |
Nucleus. Cytoplasm. Nucleus speckle. Note=Shuttles between the nucleus and the cytoplasm. Colocalizes with ACIN1 and SRSF2 in nuclear speckles.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
RNA transport, mRNA surveillance pathway
|
