SAP18

Gene Symbol	SAP18
Entrez Gene	10284
Alt Symbol	2HOR0202, SAP18P
Species	Human
Gene Type	protein-coding
Description	Sin3A-associated protein, 18kDa
Other Description	18 kDa Sin3-associated polypeptide|cell growth inhibiting protein 38|cell growth-inhibiting gene 38 protein|cell growth-inhibiting protein 38|histone deacetlyase complex subunit SAP18|histone deacetylase complex subunit SAP18|sin3-associated polypeptide p18|sin3-associated polypeptide, 18 kDa|sin3-associated polypeptide, p18
Swissprots	Q6IAW9 Q2TTR4 Q8N606 B2R494 O00422 Q9UF14
Accessions	EAX08291 O00422 AF153608 AAD41090 AK311748 BAG34691 AY550970 AAT52216 BC030836 AAH30836 BU618473 CR457035 CAG33316 DB171768 EU446760 ABZ92289 U78303 AAF21220 U96915 AAC51322 XM_011534868 XP_011533170 NM_005870 NP_005861
Function	Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. In
Subcellular Location	Nucleus. Cytoplasm. Nucleus speckle. Note=Shuttles between the nucleus and the cytoplasm. Colocalizes with ACIN1 and SRSF2 in nuclear speckles.
Tissue Specificity	Ubiquitous.
Top Pathways	RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SAP18 full length protein - ab86702 from Abcam Category Protein Source E. coli Species Human

Human SAP18 peptide - ab30465 from Abcam Category Peptide

SAP18 Antibody Blocking Peptide - LS-E3777 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SAP18 Antibody Blocking Peptide - LS-E13929 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SAP18 Recombinant Protein - H00010284-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SAP18 Protein - NBC1-28776 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Species Human

SAP18-Antibody-Center-Blocking-Peptide - BP14996c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SAP18 Protein (OPPA02239) - OPPA02239 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Sin3A-Associated Protein, 18kDa protein - orb81349 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source E.coli Species Human

SAP18 protein (His tag) - 80R-1162 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

SAP18 (20-172, His-tag) - AR09221PU-L from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

SAP18 (20-172, His-tag) - AR09221PU-N from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

SAP18 - H00010284-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SAP18 - H00010284-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Sin3A-Associated Protein 18kDa, Human Recombinant - 228-11398-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human SAP18 - 228-11398-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human SAP18 - 228-11398-3 from RayBiotech Category Protein Prices $3,180.00 Sizes 3 µg Source Escherichia Coli. Species Human

SAP18, 20- 172 aa, Human, His-tagged, Recombinant, E.coli - 01-2096 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Source E.coli Species Human

SAP18 fusion protein - ag4974 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SAP18 fusion protein - ag4795 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SAP18 Human - PRPS-714 from NeoScientific Category Protein Prices $65.00, $169.00, $3,900.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human SAP18 Protein - BP002286-PRO-707 from Syd Labs Category Protein Prices $160.00, $3,000.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

SAP18, 20- 172 aa, Recombinant Protein - GWB-P1698H from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human Sin3A-Associated Protein 18kDa - GWB-EF222E from Genway Biotech Category Protein Prices $75.00, $165.00, $3,365.00 Sizes 5 μg, 20 μg, 1000 μg Species Human

Recombinant Human Sin3A-associated Protein, 18kDa - SAP18-182H from Creative Biomart Category Protein Source E.coli .

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