Gene Symbol | TNFSF9 |
---|---|
Entrez Gene | 8744 |
Alt Symbol | 4-1BB-L, CD137L |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor (ligand) superfamily, member 9 |
Other Description | 4-1BB ligand|4-1BBL|homolog of mouse 4-1BB-L|receptor 4-1BB ligand|tumor necrosis factor ligand superfamily member 9 |
Swissprots | P41273 Q2M3S2 |
Accessions | EAW69076 EAW69077 P41273 AI357267 AK313999 BAG36711 BC104805 AAI04806 BC104807 AAI04808 BM790119 BX107825 U03398 AAA53134 XM_006722931 XP_006722994 NM_003811 NP_003802 |
Function | Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. {ECO:0000269|PubMed:20032458}. |
Subcellular Location | Membrane; Single-pass type II membrane protein. |
Tissue Specificity | Expressed in brain, placenta, lung, skeletal muscle and kidney. |
Top Pathways | Cytokine-cytokine receptor interaction |