Gene Symbol | TNFSF9 |
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Entrez Gene | 8744 |
Alt Symbol | 4-1BB-L, CD137L |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor (ligand) superfamily, member 9 |
Other Description | 4-1BB ligand|4-1BBL|homolog of mouse 4-1BB-L|receptor 4-1BB ligand|tumor necrosis factor ligand superfamily member 9 |
Swissprots | P41273 Q2M3S2 |
Accessions | EAW69076 EAW69077 P41273 AI357267 AK313999 BAG36711 BC104805 AAI04806 BC104807 AAI04808 BM790119 BX107825 U03398 AAA53134 XM_006722931 XP_006722994 NM_003811 NP_003802 |
Function | Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. {ECO:0000269|PubMed:20032458}. |
Subcellular Location | Membrane; Single-pass type II membrane protein. |
Tissue Specificity | Expressed in brain, placenta, lung, skeletal muscle and kidney. |
Top Pathways | Cytokine-cytokine receptor interaction |
CD137L CRISPR/Cas9 KO Plasmid (h) - sc-404974 from Santa Cruz Biotechnology
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CD137L HDR Plasmid (h) - sc-404974-HDR from Santa Cruz Biotechnology
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CD137L Double Nickase Plasmid (h) - sc-404974-NIC from Santa Cruz Biotechnology
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CD137L Double Nickase Plasmid (h2) - sc-404974-NIC-2 from Santa Cruz Biotechnology
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CD137L CRISPR Activation Plasmid (h) - sc-404974-ACT from Santa Cruz Biotechnology
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CD137L CRISPR Activation Plasmid (h2) - sc-404974-ACT-2 from Santa Cruz Biotechnology
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CD137L Lentiviral Activation Particles (h) - sc-404974-LAC from Santa Cruz Biotechnology
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CD137L Lentiviral Activation Particles (h2) - sc-404974-LAC-2 from Santa Cruz Biotechnology
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CD137L siRNA (h) - sc-42827 from Santa Cruz Biotechnology
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CD137L shRNA Plasmid (h) - sc-42827-SH from Santa Cruz Biotechnology
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CD137L shRNA (h) Lentiviral Particles - sc-42827-V from Santa Cruz Biotechnology
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4-1BB Ligand/TNFSF9 RNAi - H00008744-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN21770 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21770 from Sigma-Aldrich
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TNFSF9 siRNA (Human) - CRH5762 from Cohesion Biosciences
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TNFSF9 - MBS8201062 from MyBioSource
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CD137L CRISPR/Cas9 KO Plasmid (h2) - sc-404974-KO-2 from Santa Cruz Biotechnology
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CD137L HDR Plasmid (h2) - sc-404974-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TNFSF9 (NM_003811.3) - SHH432204 from Creative biogene
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TNFSF9 shRNA Plasmid (Human) - CHH5762 from Cohesion Biosciences
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TNFSF9 miRNA 3'UTR clone - MiUTR1H-10611 from Creative biogene
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