GSK3B

Gene Symbol	GSK3B
Entrez Gene	2932
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	glycogen synthase kinase 3 beta
Other Description	GSK-3 beta|GSK3beta isoform|glycogen synthase kinase-3 beta|serine/threonine-protein kinase GSK3B
Swissprots	Q9UL47 D3DN89 Q9BWH3 P49841
Accessions	AAC69340 AAD48517 CBX51856 CBX51857 CBX51858 CBX51859 EAW79533 EAW79534 EAW79535 EAW79536 P49841 AB451356 BAG70170 AK290897 BAF83586 AY123976 AAM88578 BC000251 AAH00251 BC012760 AAH12760 BX640779 CA312249 CR536510 CAG38748 DA477189 DQ892501 ABM83427 DQ895714 ABM86640 EU302497 ABX89591 L33801 AAA66475 XM_006713610 XP_006713673 XM_006713611 XP_006713674 NM_001146156 NP_001139628 NM_002093 NP_002084
Function	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquiti
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane.
Tissue Specificity	Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain. {ECO:0000269|PubMed:21029237}.
Top Pathways	Insulin signaling pathway, Cell cycle, Basal cell carcinoma, PI3K-Akt signaling pathway, B cell receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-GSK3B-cDNA-Clone - DC00103 from Abgent, a WuXi AppTec company Prices $584.55 Sizes 10 µg Species Human Accession BC000251

GSK3B - MBS1277158 from MyBioSource Species Human Accession BC000251

Human GSK3B cDNA clone(NM_001146156.1) - CDFH008097 from Creative Biomart Species Human Accession NM_001146156.1

Human GSK3B ORF Clone(NM_002093.3) - CDCL165451 from Creative Biomart Species Human Accession NM_002093.3

Human GSK3B ORF Clone(NM_001146156.1) - CDCL165452 from Creative Biomart Species Human Accession NM_001146156.1

Human GSK3B ORF Clone(NM_001146156.1) - CDCR353295 from Creative Biomart Species Human Accession NM_001146156.1

Human GSK3B ORF Clone(NM_001146156.1) - CDCR353296 from Creative Biomart Species Human Accession NM_001146156.1

Human glycogen synthase kinase 3 beta Gene cDNA Clone (full-length ORF Clone) - HG10044-M from Sino Biological Species Human Accession NM_001146156.1

Human GSK3B Gene ORF cDNA clone expression plasmid, C-His tag - HG10044-CH from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid - HG10044-UT from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid, N-HA tag - HG10044-NY from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10044-NF from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10044-ACG from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10044-CF from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10044-NM from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10044-CM from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid, N-His tag - HG10044-NH from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10044-ACR from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10044-ANR from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10044-ANG from Sino Biological Species Human

Human GSK3B Gene ORF cDNA clone expression plasmid, C-HA tag - HG10044-CY from Sino Biological Species Human

Human GSK3B ORF clone (NM_001146156.1) - CDCL115055 from Creative biogene Species Human

Human GSK3B ORF Clone (BC000251) - CDCS408594 from Creative biogene Species Human Accession P49841

Human GSK3B gene - orb90664 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human GSK3B cDNA Clone(NM_001146156.1) - CDFH008097 from Creative biogene Species Human

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