GSK3B
| Gene Symbol | GSK3B |
|---|---|
| Entrez Gene | 2932 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | glycogen synthase kinase 3 beta |
| Other Description | GSK-3 beta|GSK3beta isoform|glycogen synthase kinase-3 beta|serine/threonine-protein kinase GSK3B |
| Swissprots | Q9UL47 D3DN89 Q9BWH3 P49841 |
| Accessions | AAC69340 AAD48517 CBX51856 CBX51857 CBX51858 CBX51859 EAW79533 EAW79534 EAW79535 EAW79536 P49841 AB451356 BAG70170 AK290897 BAF83586 AY123976 AAM88578 BC000251 AAH00251 BC012760 AAH12760 BX640779 CA312249 CR536510 CAG38748 DA477189 DQ892501 ABM83427 DQ895714 ABM86640 EU302497 ABX89591 L33801 AAA66475 XM_006713610 XP_006713673 XM_006713611 XP_006713674 NM_001146156 NP_001139628 NM_002093 NP_002084 |
| Function | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquiti |
| Subcellular Location | Cytoplasm. Nucleus. Cell membrane. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane. |
| Tissue Specificity | Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain. {ECO:0000269|PubMed:21029237}. |
| Top Pathways | Insulin signaling pathway, Cell cycle, Basal cell carcinoma, PI3K-Akt signaling pathway, B cell receptor signaling pathway |
GSK-3β siRNA (h) - sc-35527 from Santa Cruz Biotechnology
|
||||||||
GSK-3β shRNA Plasmid (h) - sc-35527-SH from Santa Cruz Biotechnology
|
||||||||
GSK-3β shRNA (h) Lentiviral Particles - sc-35527-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU079451 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0874 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0873 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0872 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1024 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1024 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1262 from Sigma-Aldrich
|
||||||||
GSK3B siRNA (Human) - CRH1981 from Cohesion Biosciences
|
||||||||
GSK-3 beta RNAi - H00002932-R02 from Novus Biologicals
|
||||||||
GSK3B - MBS8233842 from MyBioSource
|
||||||||
shRNA set against Human GSK3B (NM_002093.3) - SHH308470 from Creative biogene
|
||||||||
shRNA set against Human GSK3B(NM_002093.3) - SHH106805 from Creative biogene
|
||||||||
shRNA set against Human GSK3B(NM_001146156.1) - SHH106823 from Creative biogene
|
||||||||
Human GSK3B siRNA - orb262483 from Biorbyt
|
||||||||
GSK3B shRNA Plasmid (Human) - CHH1981 from Cohesion Biosciences
|
||||||||
GSK3B miRNA 3'UTR clone - MiUTR1H-04311 from Creative biogene
|
||||||||
GSK3B miRNA 3'UTR clone - MiUTR1H-04312 from Creative biogene
|