GSK3B

Gene Symbol	GSK3B
Entrez Gene	2932
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	glycogen synthase kinase 3 beta
Other Description	GSK-3 beta|GSK3beta isoform|glycogen synthase kinase-3 beta|serine/threonine-protein kinase GSK3B
Swissprots	Q9UL47 D3DN89 Q9BWH3 P49841
Accessions	AAC69340 AAD48517 CBX51856 CBX51857 CBX51858 CBX51859 EAW79533 EAW79534 EAW79535 EAW79536 P49841 AB451356 BAG70170 AK290897 BAF83586 AY123976 AAM88578 BC000251 AAH00251 BC012760 AAH12760 BX640779 CA312249 CR536510 CAG38748 DA477189 DQ892501 ABM83427 DQ895714 ABM86640 EU302497 ABX89591 L33801 AAA66475 XM_006713610 XP_006713673 XM_006713611 XP_006713674 NM_001146156 NP_001139628 NM_002093 NP_002084
Function	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquiti
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane.
Tissue Specificity	Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain. {ECO:0000269|PubMed:21029237}.
Top Pathways	Insulin signaling pathway, Cell cycle, Basal cell carcinoma, PI3K-Akt signaling pathway, B cell receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human GSK3 beta full length protein - ab60863 from Abcam Category Protein Prices $278.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human GSK3 beta full length protein - ab63193 from Abcam Category Protein Prices $302.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

GSK3 beta (phospho Y216) peptide - ab110532 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

GSK3 beta peptide - ab41719 from Abcam Category Peptide Prices $290.00 Sizes 50 µg

Human GSK3 beta (phospho Y216) peptide - ab74641 from Abcam Category Peptide

Human GSK3 beta full length protein - ab43626 from Abcam Category Protein Source E. coli Species Human

Human GSK3 beta full length protein - ab177644 from Abcam Category Protein Source E. coli Species Human

Human GSK3 beta full length protein - ab195107 from Abcam Category Protein Source Mammalian Species Human

Human GSK3 beta peptide - ab73171 from Abcam Category Peptide

Human GSK3 beta peptide - ab73172 from Abcam Category Peptide

Human GSK3 beta peptide - ab74642 from Abcam Category Peptide

GSK3B / GSK3 Beta Antibody Blocking Peptide - LS-E3643 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GSK3B / GSK3 Beta Antibody Blocking Peptide - LS-E19692 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GSK3B / GSK3 Beta Antibody Blocking Peptide - LS-E7275 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GSK3B / GSK3 Beta Antibody Blocking Peptide - LS-E9506 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GSK-3 beta [p Ser9] Peptide - NB100-81948PEP from Novus Biologicals Category Peptide Prices $199.00 Sizes 100 µg

GSK-3 beta Recombinant Protein - H00002932-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GSK-3 beta Partial Recombinant Protein - H00002932-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GSK-3 beta Recombinant Protein - P4183 from Novus Biologicals Category Protein Prices $799.00 Sizes 100 µg Species Human

GSK-3 beta Recombinant Protein - P3867 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

GSK-3 beta Recombinant Protein - P4698 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant Human GSK-3 beta Protein - NBP1-99842 from Novus Biologicals Category Protein Prices $185.00 Sizes 10 µg Source E. coli. Species Human

GSK-3 beta Protein - NBP1-99927 from Novus Biologicals Category Protein Species Human

GSK-3 beta Peptide - P1327 from Novus Biologicals Category Peptide Species Human

GSK-3 beta Peptide - P3122 from Novus Biologicals Category Peptide Species Human

Search more