Gene Symbol | TM7SF2 |
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Entrez Gene | 7108 |
Alt Symbol | ANG1, DHCR14A, NET47 |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane 7 superfamily member 2 |
Other Description | C-14 sterol reductase|another new gene 1 protein|delta(14)-sterol reductase|delta-14-SR|putative sterol reductase SR-1|sterol C14-reductase |
Swissprots | O76062 A8K4H0 Q96E64 Q8IY06 Q96GZ1 O95982 |
Accessions | AAC21457 AAD09769 EAW74348 EAW74349 EAW74350 EAW74351 O76062 AF023676 AAC21450 AF096304 AAD09765 AK290935 BAF83624 AK296441 BAG59094 BC009052 AAH09052 BC012857 AAH12857 BC038353 AAH38353 BG771219 NM_001277233 NP_001264162 NM_003273 NP_003264 NR_102367 |
Function | Involved in the conversion of lanosterol to cholesterol. {ECO:0000269|PubMed:11784322}. |
Subcellular Location | Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:9878250}; Multi-pass membrane protein {ECO:0000269|PubMed:9878250}. |
Tissue Specificity | Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes. {ECO:0000269|PubMed:9878250}. |
Top Pathways | Steroid biosynthesis |
TM7SF2 CRISPR/Cas9 KO Plasmid (h) - sc-411040 from Santa Cruz Biotechnology
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TM7SF2 HDR Plasmid (h) - sc-411040-HDR from Santa Cruz Biotechnology
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TM7SF2 Double Nickase Plasmid (h) - sc-411040-NIC from Santa Cruz Biotechnology
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TM7SF2 Double Nickase Plasmid (h2) - sc-411040-NIC-2 from Santa Cruz Biotechnology
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TM7SF2 CRISPR Activation Plasmid (h) - sc-411040-ACT from Santa Cruz Biotechnology
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TM7SF2 CRISPR Activation Plasmid (h2) - sc-411040-ACT-2 from Santa Cruz Biotechnology
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TM7SF2 Lentiviral Activation Particles (h) - sc-411040-LAC from Santa Cruz Biotechnology
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TM7SF2 Lentiviral Activation Particles (h2) - sc-411040-LAC-2 from Santa Cruz Biotechnology
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TM7SF2 siRNA (h) - sc-96408 from Santa Cruz Biotechnology
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TM7SF2 shRNA Plasmid (h) - sc-96408-SH from Santa Cruz Biotechnology
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TM7SF2 shRNA (h) Lentiviral Particles - sc-96408-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU074031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21422 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21422 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00274 from Sigma-Aldrich
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TM7SF2 siRNA (Human) - CRH4875 from Cohesion Biosciences
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TM7SF2 - MBS8230450 from MyBioSource
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shRNA set against Human TM7SF2 (NM_003273.2) - SHH428220 from Creative biogene
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shRNA set against Human TM7SF2(NM_003273.2) - SHG057727 from Creative biogene
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Human TM7SF2 siRNA - orb265377 from Biorbyt
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TM7SF2 shRNA Plasmid (Human) - CHH4875 from Cohesion Biosciences
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TM7SF2 miRNA 3'UTR clone - MiUTR1H-10448 from Creative biogene
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