| Gene Symbol |
DET1
|
| Entrez Gene |
55070
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
de-etiolated homolog 1 (Arabidopsis)
|
| Other Description |
DET1 homolog|de-etiolated 1|de-etiolated-1 homolog
|
| Swissprots |
Q9NWD5 B3KNN6 Q2VPC0 Q7L5Y6
|
| Accessions |
CAD34982 CAE88994 EAX02003 EAX02004 EAX02005 EAX02006 Q7L5Y6 AB073887 AK000965 BAA91447 AK054603 BAG51398 BC001242 AAH01242 BC064591 BC073867 BC109060 AAI09061 BC109061 AAI09062 DA655836 XM_011521747 XP_011520049 XM_011521748 XP_011520050 XM_011521749 XP_011520051 XM_011521750 XP_011520052 XM_011521751 XP_011520053 NM_001144074 NP_001137546 NM_017996 NP_060466 NR_026645
|
| Function |
Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. {ECO:0000269|PubMed:14739464}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in the ovary, some lymphoid organs and resting leukocytes. {ECO:0000269|PubMed:14739464}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|
![Western Blot: DET1 Overexpression Lysate (Adult Normal) [NBP2-06888] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DET1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8296_DET1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06888-img0001.jpg)