| Gene Symbol | Pea15 |
|---|---|
| Entrez Gene | 364052 |
| Alt Symbol | Pea15a |
| Species | Rat |
| Gene Type | protein-coding |
| Description | phosphoprotein enriched in astrocytes 15 |
| Other Description | 15 kDa phosphoprotein enriched in astrocytes|astrocytic phosphoprotein PEA-15|phosphoprotein enriched in astrocytes 15A |
| Swissprots | Q5U318 Q78ZC9 |
| Accessions | EDL94690 EDL94691 EDL94692 Q5U318 AJ243949 CAB51573 BC085766 AAH85766 FQ235065 NM_001013231 NP_001013249 |
| Function | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Note=Associated with microtubules. {ECO:0000250}. |
CompoZr® Knockout ZFN Kit - CKOZFN59940 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND59940 from Sigma-Aldrich
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PEA15 siRNA (Rat) - CRR6231 from Cohesion Biosciences
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shRNA set against Rat PEA15 (NM_001013231.1) - SHH373316 from Creative biogene
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Rat PEA15 siRNA - orb301080 from Biorbyt
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PEA15 shRNA Plasmid (Rat) - CHR6231 from Cohesion Biosciences
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PEA15A miRNA 3'UTR clone - MiUTR1R-05751 from Creative biogene
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