NDE1

Gene Symbol	NDE1
Entrez Gene	54820
Alt Symbol	HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1
Species	Human
Gene Type	protein-coding
Description	nudE neurodevelopment protein 1
Other Description	LIS1-interacting protein NUDE1, rat homolog|nuclear distribution protein nudE homolog 1|nudE nuclear distribution E homolog 1|nudE nuclear distribution gene E homolog 1
Swissprots	Q9NXR1 Q49AQ2
Accessions	EAW53931 EAW53932 EAW53933 Q9NXR1 AF124431 AK000108 BAA90949 AK025815 AK127927 BC001421 AAH01421 BC033900 AAH33900 BP271845 KJ534887 AHW56527 KJ534967 AHW56607 KJ534991 AHW56631 KJ535028 AHW56667 XM_005255396 XP_005255453 XM_006720897 XP_006720960 XM_006720898 XP_006720961 XM_006720899 XP_006720962 XM_006720900 XP_006720963 XM_006725200 XP_006725263 XM_006725201 XP_006725264 XM_006725202 XP_006725265 XM_006725203 XP_006725266 XM_006725204 XP_006725267 XM_011522549 XP_011520851 XM_011522550 XP_011520852 XM_011522551 XP_011520853 XM_011522552 XP_011520854 XM_011522553 XP_011520855 XM_011522554 XP_011520856 XM_011546707 XP_011545009 XM_011546708 XP_011545010 XM_011546709 XP_011545011 XM_011546710 XP_011545012 XM_011546711 XP_011545013 XM_011546712 XP_011545014 NM_001143979 NP_001137451 NM_017668 NP_060138
Function	Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752}.
Subcellular Location	Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF- dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis.
Tissue Specificity	Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum. {ECO:0000269|PubMed:21529752}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NUDE1 (D-19) - sc-168801 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

NUDE1 (36-T) - sc-100328 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-NDE1 antibody - ab127032 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 antibody - ab57430 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-NDE1 antibody - ab76384 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 antibody - ab86075 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 antibody [AT1F7] - ab136630 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone AT1F7

Anti-NDE1 / NUDE Antibody (N-Terminus, AP) - LS-C220141 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody (N-Terminus, APC) - LS-C220143 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody (N-Terminus, Biotin) - LS-C220144 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody (N-Terminus, FITC) - LS-C220145 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody (N-Terminus, Azide-free, HRP) - LS-C220146 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody (N-Terminus, PE) - LS-C220147 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody (aa50-100) - LS-C288732 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody (aa200-250) - LS-C288733 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody (aa1-336, Azide-free) - LS-C328083 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-NDE1 / NUDE Antibody (aa275-325) - LS-C288735 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody (N-Terminus) - LS-C330562 from LifeSpan Bioscience Prices $425.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody - LS-C155535 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody - LS-C346235 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NDE1 / NUDE Antibody (clone AT1F7) - LS-C175807 from LifeSpan Bioscience Prices $315.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone AT1F7

Anti-NDE1 / NUDE Antibody (N-Terminus, clone EPR5068) - LS-C138644 from LifeSpan Bioscience Prices $485.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5068

Anti-NDE1 / NUDE Antibody (aa218-267) IHC-plus™ - LS-B5804 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

NDE1 Antibody - NBP1-53097 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

NDE1 Antibody (2G11-1C11) - H00054820-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2G11-1C11

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