NDE1

Gene Symbol	NDE1
Entrez Gene	54820
Alt Symbol	HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1
Species	Human
Gene Type	protein-coding
Description	nudE neurodevelopment protein 1
Other Description	LIS1-interacting protein NUDE1, rat homolog|nuclear distribution protein nudE homolog 1|nudE nuclear distribution E homolog 1|nudE nuclear distribution gene E homolog 1
Swissprots	Q9NXR1 Q49AQ2
Accessions	EAW53931 EAW53932 EAW53933 Q9NXR1 AF124431 AK000108 BAA90949 AK025815 AK127927 BC001421 AAH01421 BC033900 AAH33900 BP271845 KJ534887 AHW56527 KJ534967 AHW56607 KJ534991 AHW56631 KJ535028 AHW56667 XM_005255396 XP_005255453 XM_006720897 XP_006720960 XM_006720898 XP_006720961 XM_006720899 XP_006720962 XM_006720900 XP_006720963 XM_006725200 XP_006725263 XM_006725201 XP_006725264 XM_006725202 XP_006725265 XM_006725203 XP_006725266 XM_006725204 XP_006725267 XM_011522549 XP_011520851 XM_011522550 XP_011520852 XM_011522551 XP_011520853 XM_011522552 XP_011520854 XM_011522553 XP_011520855 XM_011522554 XP_011520856 XM_011546707 XP_011545009 XM_011546708 XP_011545010 XM_011546709 XP_011545011 XM_011546710 XP_011545012 XM_011546711 XP_011545013 XM_011546712 XP_011545014 NM_001143979 NP_001137451 NM_017668 NP_060138
Function	Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752}.
Subcellular Location	Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF- dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis.
Tissue Specificity	Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum. {ECO:0000269|PubMed:21529752}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NDE1 full length protein - ab106891 from Abcam Category Protein Source E. coli Species Human

Human NDE1 full length protein - ab125486 from Abcam Category Protein Source E. coli Species Human

NDE1 / NUDE Antibody Blocking Peptide - LS-E17350 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NDE1 Recombinant Protein - H00054820-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NDE1 Protein - NBP1-51090 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

NDE1-Antibody-N-term-Blocking-Peptide - BP8800a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human NDE1 protein - orb168907 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

NDE1 Blocking Peptide - 33R-1254 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NDE1 protein (His tag) - 80R-1784 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

NDE1 (1-335, His-tag) - AR09967PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

NDE1 (1-335, His-tag) - AR09967PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

NDE1 - H00054820-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NDE1 - H00054820-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NDE1, 1-335aa, Human, His tag, E.coli - 01-P1027 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

NDE1 fusion protein - Ag18174 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

NDE1 fusion protein - Ag0336 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

NDE1 fusion protein - ag19175 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NDE1 Human - PRPS-211 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human NDE1 Protein - BP002936-PRO-204 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-?derived. Species Human

NDE1, 1-335aa, Recombinant Protein - GWB-P1011J from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

NDE1 Human Protein - GWB-BSP550 from Genway Biotech Category Protein Prices $75.00, $165.00, $3,230.00 Sizes 5 μg, 20 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human NDE1, His-tagged - NDE1-3514H from Creative Biomart Category Protein

Recombinant Human NDE1, His-tagged - NDE1-28795TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human NDE1, GST-tagged - NDE1-1218H from Creative Biomart Category Protein Source E.coli Species Human

NDE1 - NKX-309 from Reagent Proteins Category Protein Prices $364.00, $2,898.00 Sizes 20.00 µg, 1 mg Source E.coli

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