Gene Symbol | RNASEH2A |
---|---|
Entrez Gene | 10535 |
Alt Symbol | AGS4, JUNB, RNASEHI, RNHIA, RNHL |
Species | Human |
Gene Type | protein-coding |
Description | ribonuclease H2, subunit A |
Other Description | RNase H(35)|RNase H2 subunit A|RNase HI large subunit|aicardi-Goutieres syndrome 4 protein|ribonuclease H2 subunit A|ribonuclease H2, large subunit|ribonuclease HI large subunit|ribonuclease HI subunit A|ribonuclease HI, large subunit |
Swissprots | O75792 B2RCY1 Q96F11 |
Accessions | EAW84313 O75792 AK315327 BAG37728 AY363912 AAQ64005 BC011748 AAH11748 BE560339 BG825340 BM664190 CB240995 CR456841 CAG33122 Z97029 CAB09725 XM_006722619 XP_006722682 NM_006397 NP_006388 |
Function | Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Top Pathways | DNA replication |