Gene Symbol | RNASEH2A |
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Entrez Gene | 10535 |
Alt Symbol | AGS4, JUNB, RNASEHI, RNHIA, RNHL |
Species | Human |
Gene Type | protein-coding |
Description | ribonuclease H2, subunit A |
Other Description | RNase H(35)|RNase H2 subunit A|RNase HI large subunit|aicardi-Goutieres syndrome 4 protein|ribonuclease H2 subunit A|ribonuclease H2, large subunit|ribonuclease HI large subunit|ribonuclease HI subunit A|ribonuclease HI, large subunit |
Swissprots | O75792 B2RCY1 Q96F11 |
Accessions | EAW84313 O75792 AK315327 BAG37728 AY363912 AAQ64005 BC011748 AAH11748 BE560339 BG825340 BM664190 CB240995 CR456841 CAG33122 Z97029 CAB09725 XM_006722619 XP_006722682 NM_006397 NP_006388 |
Function | Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Top Pathways | DNA replication |
RNase HII-A CRISPR/Cas9 KO Plasmid (h) - sc-405715 from Santa Cruz Biotechnology
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RNase HII-A HDR Plasmid (h) - sc-405715-HDR from Santa Cruz Biotechnology
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RNase HII-A Double Nickase Plasmid (h) - sc-405715-NIC from Santa Cruz Biotechnology
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RNase HII-A Double Nickase Plasmid (h2) - sc-405715-NIC-2 from Santa Cruz Biotechnology
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RNase HII-A CRISPR Activation Plasmid (h) - sc-405715-ACT from Santa Cruz Biotechnology
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RNase HII-A CRISPR Activation Plasmid (h2) - sc-405715-ACT-2 from Santa Cruz Biotechnology
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RNase HII-A Lentiviral Activation Particles (h) - sc-405715-LAC from Santa Cruz Biotechnology
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RNase HII-A Lentiviral Activation Particles (h2) - sc-405715-LAC-2 from Santa Cruz Biotechnology
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RNase HII-A siRNA (h) - sc-62954 from Santa Cruz Biotechnology
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RNase HII-A shRNA Plasmid (h) - sc-62954-SH from Santa Cruz Biotechnology
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RNase HII-A shRNA (h) Lentiviral Particles - sc-62954-V from Santa Cruz Biotechnology
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RNASEH2A RNAi - H00010535-R01V from Novus Biologicals
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RNASEH2A RNAi - H00010535-R01 from Novus Biologicals
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MISSION® esiRNA - EHU019231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18353 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18353 from Sigma-Aldrich
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RNASEH2A siRNA (Human) - CRH7160 from Cohesion Biosciences
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RNASEH2A - MBS8220791 from MyBioSource
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shRNA set against Human RNASEH2A (NM_006397.2) - SHH396372 from Creative biogene
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shRNA set against Human RNASEH2A(NM_006397.2) - SHR184278 from Creative biogene
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Human RNASEH2A siRNA - orb267662 from Biorbyt
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RNASEH2A shRNA Plasmid (Human) - CHH7160 from Cohesion Biosciences
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RNASEH2A miRNA 3'UTR clone - MiUTR1H-08862 from Creative biogene
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