| Gene Symbol |
ERLIN1
|
| Entrez Gene |
10613
|
| Alt Symbol |
C10orf69, Erlin-1, KE04, KEO4, SPFH1, SPG62
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ER lipid raft associated 1
|
| Other Description |
Band_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9|SPFH domain family, member 1|SPFH domain-containing protein 1|endoplasmic reticulum lipid raft-associated protein 1|erlin-1|stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1
|
| Swissprots |
O75477 Q53HV0 B0QZ42
|
| Accessions |
EAW49846 EAW49847 O75477 AF064093 AAC26658 AK056574 AK127017 AK222480 BAD96200 AK298427 BAG60649 AK315580 BAG37953 BC031791 AAH31791 BP280488 BQ101058 BU192550 DQ894532 ABM85458 EU176273 ABW03724 XM_005269442 XP_005269499 XM_011539170 XP_011537472 XM_011539171 XP_011537473 NM_001100626 NP_001094096 NM_006459 NP_006450
|
| Function |
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). {ECO:0000269|PubMed:19240031}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:11118313, ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:19240031}; Single-pass type II membrane protein {ECO:0000269|PubMed:11118313, ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:19240031}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
|
| Tissue Specificity |
Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine. {ECO:0000269|PubMed:11118313}.
|