Gene Symbol | ERLIN1 |
---|---|
Entrez Gene | 10613 |
Alt Symbol | C10orf69, Erlin-1, KE04, KEO4, SPFH1, SPG62 |
Species | Human |
Gene Type | protein-coding |
Description | ER lipid raft associated 1 |
Other Description | Band_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9|SPFH domain family, member 1|SPFH domain-containing protein 1|endoplasmic reticulum lipid raft-associated protein 1|erlin-1|stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1 |
Swissprots | O75477 Q53HV0 B0QZ42 |
Accessions | EAW49846 EAW49847 O75477 AF064093 AAC26658 AK056574 AK127017 AK222480 BAD96200 AK298427 BAG60649 AK315580 BAG37953 BC031791 AAH31791 BP280488 BQ101058 BU192550 DQ894532 ABM85458 EU176273 ABW03724 XM_005269442 XP_005269499 XM_011539170 XP_011537472 XM_011539171 XP_011537473 NM_001100626 NP_001094096 NM_006459 NP_006450 |
Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). {ECO:0000269|PubMed:19240031}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:11118313, ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:19240031}; Single-pass type II membrane protein {ECO:0000269|PubMed:11118313, ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:19240031}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. |
Tissue Specificity | Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine. {ECO:0000269|PubMed:11118313}. |
SPFH1 CRISPR/Cas9 KO Plasmid (h) - sc-406255 from Santa Cruz Biotechnology
|
||||||||
SPFH1 HDR Plasmid (h) - sc-406255-HDR from Santa Cruz Biotechnology
|
||||||||
SPFH1 Double Nickase Plasmid (h) - sc-406255-NIC from Santa Cruz Biotechnology
|
||||||||
SPFH1 Double Nickase Plasmid (h2) - sc-406255-NIC-2 from Santa Cruz Biotechnology
|
||||||||
SPFH1 CRISPR Activation Plasmid (h) - sc-406255-ACT from Santa Cruz Biotechnology
|
||||||||
SPFH1 CRISPR Activation Plasmid (h2) - sc-406255-ACT-2 from Santa Cruz Biotechnology
|
||||||||
SPFH1 Lentiviral Activation Particles (h) - sc-406255-LAC from Santa Cruz Biotechnology
|
||||||||
SPFH1 Lentiviral Activation Particles (h2) - sc-406255-LAC-2 from Santa Cruz Biotechnology
|
||||||||
SPFH1 siRNA (h) - sc-90434 from Santa Cruz Biotechnology
|
||||||||
SPFH1 shRNA Plasmid (h) - sc-90434-SH from Santa Cruz Biotechnology
|
||||||||
SPFH1 shRNA (h) Lentiviral Particles - sc-90434-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN7968 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7968 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR10828 from Sigma-Aldrich
|
||||||||
ERLIN1 siRNA (Human) - CRH7226 from Cohesion Biosciences
|
||||||||
ERLIN1 - MBS8230270 from MyBioSource
|
||||||||
shRNA set against Human ERLIN1 (NM_006459.3) - SHH287121 from Creative biogene
|
||||||||
Human ERLIN1 siRNA - orb267728 from Biorbyt
|
||||||||
ERLIN1 shRNA Plasmid (Human) - CHH7226 from Cohesion Biosciences
|
||||||||
ERLIN1 miRNA 3'UTR clone - MiUTR1H-03299 from Creative biogene
|