| Gene Symbol |
Cmklr1
|
| Entrez Gene |
14747
|
| Alt Symbol |
ChemR23, DEZ, Gpcr27, mcmklr1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
chemokine-like receptor 1
|
| Other Description |
G-protein coupled receptor 27|G-protein coupled receptor DEZ|chemerin receptor|chemokine receptor-like 1
|
| Swissprots |
P97468
|
| Accessions |
EDL19943 P97468 AK158424 BAE34502 BC100612 AAI00613 BY347978 U79525 AAB53789 XM_006530164 XP_006530227 XM_006530165 XP_006530228 XM_006530166 XP_006530229 NM_008153 NP_032179
|
| Function |
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B (By similarity). Positively regulates adipogenesis and adipocyte metabolism. {ECO:0000250, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:16863918, ECO:0000269|PubMed:17635925}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16863918}; Multi-pass membrane protein {ECO:0000269|PubMed:16863918}.
|
| Tissue Specificity |
Expressed in the differentiated adipocytes (at protein level). Ubiquitous. Highly expressed in adipose tissue and immature plasmacytoid dendritic cells (DCs) and at lower levels in myeloid DCs, macrophages, and NK cells. Expressed on macrophages isolated from different tissues, including peritoneal cavities, pleural cavities and spleen. {ECO:0000269|PubMed:16863918, ECO:0000269|PubMed:17635925, ECO:0000269|PubMed:17767914, ECO:0000269|PubMed:18242188, ECO:0000269|PubMed:19841182}.
|