Cmklr1

Gene Symbol Cmklr1
Entrez Gene 14747
Alt Symbol ChemR23, DEZ, Gpcr27, mcmklr1
Species Mouse
Gene Type protein-coding
Description chemokine-like receptor 1
Other Description G-protein coupled receptor 27|G-protein coupled receptor DEZ|chemerin receptor|chemokine receptor-like 1
Swissprots P97468
Accessions EDL19943 P97468 AK158424 BAE34502 BC100612 AAI00613 BY347978 U79525 AAB53789 XM_006530164 XP_006530227 XM_006530165 XP_006530228 XM_006530166 XP_006530229 NM_008153 NP_032179
Function Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B (By similarity). Positively regulates adipogenesis and adipocyte metabolism. {ECO:0000250, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:16863918, ECO:0000269|PubMed:17635925}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:16863918}; Multi-pass membrane protein {ECO:0000269|PubMed:16863918}.
Tissue Specificity Expressed in the differentiated adipocytes (at protein level). Ubiquitous. Highly expressed in adipose tissue and immature plasmacytoid dendritic cells (DCs) and at lower levels in myeloid DCs, macrophages, and NK cells. Expressed on macrophages isolated from different tissues, including peritoneal cavities, pleural cavities and spleen. {ECO:0000269|PubMed:16863918, ECO:0000269|PubMed:17635925, ECO:0000269|PubMed:17767914, ECO:0000269|PubMed:18242188, ECO:0000269|PubMed:19841182}.

ChemR23 CRISPR/Cas9 KO Plasmid (m) - sc-420645 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ChemR23 HDR Plasmid (m) - sc-420645-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ChemR23 Double Nickase Plasmid (m) - sc-420645-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ChemR23 Double Nickase Plasmid (m2) - sc-420645-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ChemR23 CRISPR Activation Plasmid (m) - sc-420645-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ChemR23 CRISPR Activation Plasmid (m2) - sc-420645-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ChemR23 Lentiviral Activation Particles (m) - sc-420645-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ChemR23 Lentiviral Activation Particles (m2) - sc-420645-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ChemR23 siRNA (m) - sc-44634 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

ChemR23 shRNA Plasmid (m) - sc-44634-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

ChemR23 shRNA (m) Lentiviral Particles - sc-44634-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU090061 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN28927 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28927 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CMKLR1 siRNA (Mouse) - CRM1651 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

CMKLR1 - MBS8233106 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse CMKLR1 (NM_008153.3) - SHH265905 from Creative biogene

Category siRNA
Species Reactivities Mouse

CMKLR1 shRNA Plasmid (Mouse) - CHM1651 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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