| Gene Symbol |
SYMPK
|
| Entrez Gene |
8189
|
| Alt Symbol |
SPK, SYM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
symplekin
|
| Other Description |
-
|
| Swissprots |
O00521 Q59GT5 Q92797 Q8N2U5 O00733 O00689
|
| Accessions |
EAW57389 EAW57390 EAW57391 EAW57392 EAW57393 Q92797 AB209024 BAD92261 AB210010 BAE06092 AF049526 AAC27504 AK130602 AK300252 BAH13243 BC006536 AAH06536 BC006567 AAH06567 BC030214 AAH30214 BU752018 BX649165 DB044963 DB461873 DQ893447 ABM84373 EU176761 ABW03562 U49240 AAC50667 U88726 AAB58578 Y10931 CAA71861 XM_005259286 XP_005259343 XM_011527354 XP_011525656 XM_011527355 XP_011525657 XR_243962 NM_004819 NP_004810
|
| Function |
Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house- keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Nucleus, nucleoplasm. Note=Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells.
|
| Tissue Specificity |
In testis, expressed in polar epithelia and Sertoli cells but not in vascular endothelia. The protein is detected in stomach, duodenum, pancreas, liver, fetal brain, carcinomas, lens-forming cells, fibroblasts, lymphocytes, lymphoma cells, erythroleukemia cells but not in endothelium of vessels, epidermis, intercalated disks, Purkinje fiber cells of the heart and lymph node. {ECO:0000269|PubMed:8769423}.
|
| Top Pathways |
Tight junction, mRNA surveillance pathway
|