SYMPK

Gene Symbol	SYMPK
Entrez Gene	8189
Alt Symbol	SPK, SYM
Species	Human
Gene Type	protein-coding
Description	symplekin
Other Description	-
Swissprots	O00521 Q59GT5 Q92797 Q8N2U5 O00733 O00689
Accessions	EAW57389 EAW57390 EAW57391 EAW57392 EAW57393 Q92797 AB209024 BAD92261 AB210010 BAE06092 AF049526 AAC27504 AK130602 AK300252 BAH13243 BC006536 AAH06536 BC006567 AAH06567 BC030214 AAH30214 BU752018 BX649165 DB044963 DB461873 DQ893447 ABM84373 EU176761 ABW03562 U49240 AAC50667 U88726 AAB58578 Y10931 CAA71861 XM_005259286 XP_005259343 XM_011527354 XP_011525656 XM_011527355 XP_011525657 XR_243962 NM_004819 NP_004810
Function	Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house- keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}.
Subcellular Location	Cytoplasm, cytoskeleton. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Nucleus, nucleoplasm. Note=Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells.
Tissue Specificity	In testis, expressed in polar epithelia and Sertoli cells but not in vascular endothelia. The protein is detected in stomach, duodenum, pancreas, liver, fetal brain, carcinomas, lens-forming cells, fibroblasts, lymphocytes, lymphoma cells, erythroleukemia cells but not in endothelium of vessels, epidermis, intercalated disks, Purkinje fiber cells of the heart and lymph node. {ECO:0000269|PubMed:8769423}.
Top Pathways	Tight junction, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Symplekin full length protein - ab159958 from Abcam Category Protein Source Wheat germ Species Human

SYMPK / Symplekin Antibody Blocking Peptide - LS-E15786 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYMPK / Symplekin Antibody Blocking Peptide - LS-E15785 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Symplekin Protein - H00008189-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PBK protein (His tag) - 80R-2181 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

Symplekin Blocking Peptide - 33R-3475 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Symplekin Blocking Peptide - 33R-8224 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Symplekin / SYMPK - H00008189-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Symplekin / SYMPK - H00008189-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SYMPK fusion protein - Ag2081 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human SPK, His-tagged - SPK-2924H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human SYMPK, GST-tagged - SYMPK-3070H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Symplekin(SYMPK) ,partial - CSB-YP023001HU CSB-EP023001HU CSB-BP023001HU CSB-MP023001HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Symplekin / SYMPK - TP316742 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Symplekin (SYMPK) - RPC882Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Symplekin (SYMPK) - RPC882Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Symplekin Protein - NBP1-92464PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SYMPK Peptide, Human - M34GP15460H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Symplekin (SYMPK) - RPU51417 from Biomatik Category Protein Prices $172.00, $353.00, $539.00, $674.24 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

SYMPK Recombinant Protein (OPCD00831) - OPCD00831 from Aviva Systems Biology Category Protein Source E.coli Species Human

Symplekin, Recombinant Protein - MBS2033107 from MyBioSource Category Protein Prices $170.00, $355.00, $550.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Symplekin (SYMPK), partial, Recombinant Protein - MBS1365669 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Symplekin Recombinant Protein Antigen - NBP2-59014PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

SYMPK fusion protein - Ag25112 from Proteintech Group Category Protein Source E. coli -derived, PET30a Species Human

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