| Gene Symbol |
RQCD1
|
| Entrez Gene |
9125
|
| Alt Symbol |
CNOT9, CT129, RCD-1, RCD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RCD1 required for cell differentiation1 homolog (S. pombe)
|
| Other Description |
CCR4-NOT transcription complex subunit 9|cancer/testis antigen 129|cell differentiation protein RCD1 homolog|protein involved in sexual development
|
| Swissprots |
Q92600 Q96IX4 B2RPI0 B5MDQ4 B7Z1E5
|
| Accessions |
BAA13508 EAW70624 EAW70625 Q92600 AA806815 AB500892 BAJ07307 AK293281 BAH11481 AK296037 BAG58803 AK316567 BAG38156 BC007102 AAH07102 BC137455 AAI37456 BC137456 AAI37457 DC299874 XM_011512138 XP_011510440 NM_001271634 NP_001258563 NM_001271635 NP_001258564 NM_005444 NP_005435 NR_073390
|
| Function |
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. {ECO:0000250, ECO:0000269|PubMed:17189474, ECO:0000269|PubMed:18180299}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
|
| Tissue Specificity |
Detected in spleen, thymus, prostate, testis, ovary and intestine. {ECO:0000269|PubMed:9447985}.
|
| Top Pathways |
RNA degradation
|