RQCD1

Gene Symbol RQCD1
Entrez Gene 9125
Alt Symbol CNOT9, CT129, RCD-1, RCD1
Species Human
Gene Type protein-coding
Description RCD1 required for cell differentiation1 homolog (S. pombe)
Other Description CCR4-NOT transcription complex subunit 9|cancer/testis antigen 129|cell differentiation protein RCD1 homolog|protein involved in sexual development
Swissprots Q92600 Q96IX4 B2RPI0 B5MDQ4 B7Z1E5
Accessions BAA13508 EAW70624 EAW70625 Q92600 AA806815 AB500892 BAJ07307 AK293281 BAH11481 AK296037 BAG58803 AK316567 BAG38156 BC007102 AAH07102 BC137455 AAI37456 BC137456 AAI37457 DC299874 XM_011512138 XP_011510440 NM_001271634 NP_001258563 NM_001271635 NP_001258564 NM_005444 NP_005435 NR_073390
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. {ECO:0000250, ECO:0000269|PubMed:17189474, ECO:0000269|PubMed:18180299}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
Tissue Specificity Detected in spleen, thymus, prostate, testis, ovary and intestine. {ECO:0000269|PubMed:9447985}.
Top Pathways RNA degradation

RQCD1 CRISPR/Cas9 KO Plasmid (h) - sc-411245 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RQCD1 HDR Plasmid (h) - sc-411245-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RQCD1 Double Nickase Plasmid (h) - sc-411245-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RQCD1 Double Nickase Plasmid (h2) - sc-411245-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RQCD1 CRISPR Activation Plasmid (h) - sc-411245-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RQCD1 CRISPR Activation Plasmid (h2) - sc-411245-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RQCD1 Lentiviral Activation Particles (h) - sc-411245-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RQCD1 Lentiviral Activation Particles (h2) - sc-411245-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RQCD1 siRNA (h) - sc-94449 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RQCD1 shRNA Plasmid (h) - sc-94449-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RQCD1 shRNA (h) Lentiviral Particles - sc-94449-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU123821 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18674 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18674 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RQCD1 siRNA (Human) - CRH6032 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RQCD1 - MBS8227614 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RQCD1 (NM_005444.2) - SHH399820 from Creative biogene

Category siRNA
Species Reactivities Human

RQCD1 shRNA Plasmid (Human) - CHH6032 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RQCD1 miRNA 3'UTR clone - MiUTR4H-TG07690 from Creative biogene

Species Reactivities Human
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