| Gene Symbol |
EGF
|
| Entrez Gene |
1950
|
| Alt Symbol |
HOMG4, URG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
epidermal growth factor
|
| Other Description |
beta-urogastrone|pro-epidermal growth factor
|
| Swissprots |
Q52LZ6 P01133 B4DRK7 E9PBF0 E7EVD2
|
| Accessions |
AAR84237 CCQ43157 EAX06257 P01133 AI628974 AK299306 BAG61319 AK307734 AY548762 AAS83395 BC093731 AAH93731 BC113461 AAI13462 BC143357 CA437074 CU446298 DB227969 DB349864 J02548 AAA72173 JQ346088 AFA26280 X04571 CAA28240 XM_005262796 XP_005262853 XM_005262797 XP_005262854 XM_005262798 XP_005262855 XM_005262800 XP_005262857 XM_005262801 XP_005262858 XM_005262802 XP_005262859 XM_006714124 XP_006714187 XM_011531707 XP_011530009 XM_011531708 XP_011530010 XM_011531709 XP_011530011 XR_427532 XR_938699 NM_001178130 NP_001171601 NM_001178131 NP_001171602 NM_001963 NP_001954
|
| Function |
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. {ECO:0000269|PubMed:17671655}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in kidney, salivary gland, cerebrum and prostate. {ECO:0000269|PubMed:17671655}.
|
| Top Pathways |
Endocytosis, Rap1 signaling pathway, Hepatitis C, PI3K-Akt signaling pathway, Choline metabolism in cancer
|