| Gene Symbol |
EID3
|
| Entrez Gene |
493861
|
| Alt Symbol |
NS4EB, NSE4B, NSMCE4B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
EP300 interacting inhibitor of differentiation 3
|
| Other Description |
E1A-like inhibitor of differentiation 3|EID-1-like inhibitor of differentiation 3|EID-3|EP300-interacting inhibitor of differentiation 3|non-SMC element 4 homolog B|non-structural maintenance of chromosomes element 4 homolog B
|
| Swissprots |
Q8N140
|
| Accessions |
EAW97747 Q8N140 AK098698 BAC05385 BC027612 AAH27612 BI461575 NM_001008394 NP_001008395
|
| Function |
Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. {ECO:0000269|PubMed:15987788}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15987788}. Cytoplasm {ECO:0000269|PubMed:15987788}. Chromosome, telomere {ECO:0000305|PubMed:15987788}. Note=May shuttle between nucleus and cytoplasm. {ECO:0000269|PubMed:15987788}.
|
| Tissue Specificity |
Highly expressed in testis. {ECO:0000269|PubMed:15987788}.
|