Gene Symbol | EID3 |
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Entrez Gene | 493861 |
Alt Symbol | NS4EB, NSE4B, NSMCE4B |
Species | Human |
Gene Type | protein-coding |
Description | EP300 interacting inhibitor of differentiation 3 |
Other Description | E1A-like inhibitor of differentiation 3|EID-1-like inhibitor of differentiation 3|EID-3|EP300-interacting inhibitor of differentiation 3|non-SMC element 4 homolog B|non-structural maintenance of chromosomes element 4 homolog B |
Swissprots | Q8N140 |
Accessions | EAW97747 Q8N140 AK098698 BAC05385 BC027612 AAH27612 BI461575 NM_001008394 NP_001008395 |
Function | Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. {ECO:0000269|PubMed:15987788}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15987788}. Cytoplasm {ECO:0000269|PubMed:15987788}. Chromosome, telomere {ECO:0000305|PubMed:15987788}. Note=May shuttle between nucleus and cytoplasm. {ECO:0000269|PubMed:15987788}. |
Tissue Specificity | Highly expressed in testis. {ECO:0000269|PubMed:15987788}. |
EID-3 CRISPR/Cas9 KO Plasmid (h) - sc-416073 from Santa Cruz Biotechnology
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EID-3 HDR Plasmid (h) - sc-416073-HDR from Santa Cruz Biotechnology
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EID-3 Double Nickase Plasmid (h) - sc-416073-NIC from Santa Cruz Biotechnology
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EID-3 Double Nickase Plasmid (h2) - sc-416073-NIC-2 from Santa Cruz Biotechnology
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EID-3 CRISPR Activation Plasmid (h) - sc-416073-ACT from Santa Cruz Biotechnology
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EID-3 CRISPR Activation Plasmid (h2) - sc-416073-ACT-2 from Santa Cruz Biotechnology
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EID-3 Lentiviral Activation Particles (h) - sc-416073-LAC from Santa Cruz Biotechnology
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EID-3 Lentiviral Activation Particles (h2) - sc-416073-LAC-2 from Santa Cruz Biotechnology
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EID-3 siRNA (h) - sc-95824 from Santa Cruz Biotechnology
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EID-3 shRNA Plasmid (h) - sc-95824-SH from Santa Cruz Biotechnology
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EID-3 shRNA (h) Lentiviral Particles - sc-95824-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN7734 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7734 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02212 from Sigma-Aldrich
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EID3 siRNA (Human) - CRJ8359 from Cohesion Biosciences
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EID3 - MBS8207614 from MyBioSource
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shRNA set against Human EID3 (NM_001008394.2) - SHH284117 from Creative biogene
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Human EID3 siRNA - orb278860 from Biorbyt
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EID3 shRNA Plasmid (Human) - CHJ8359 from Cohesion Biosciences
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EID3 miRNA 3'UTR clone - MiUTR3H-12713 from Creative biogene
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