Gene Symbol | EID3 |
---|---|
Entrez Gene | 493861 |
Alt Symbol | NS4EB, NSE4B, NSMCE4B |
Species | Human |
Gene Type | protein-coding |
Description | EP300 interacting inhibitor of differentiation 3 |
Other Description | E1A-like inhibitor of differentiation 3|EID-1-like inhibitor of differentiation 3|EID-3|EP300-interacting inhibitor of differentiation 3|non-SMC element 4 homolog B|non-structural maintenance of chromosomes element 4 homolog B |
Swissprots | Q8N140 |
Accessions | EAW97747 Q8N140 AK098698 BAC05385 BC027612 AAH27612 BI461575 NM_001008394 NP_001008395 |
Function | Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. {ECO:0000269|PubMed:15987788}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15987788}. Cytoplasm {ECO:0000269|PubMed:15987788}. Chromosome, telomere {ECO:0000305|PubMed:15987788}. Note=May shuttle between nucleus and cytoplasm. {ECO:0000269|PubMed:15987788}. |
Tissue Specificity | Highly expressed in testis. {ECO:0000269|PubMed:15987788}. |